Metirozin
(Preusmjereno sa stranice NHTGHBARYWONDQ-JTQLQIEISA-N)
Metirozin (α-Metiltirozin, Metirozin, AMPT) je antihipertenzivni lek. On inhibira enzim tirozinska hidroksilaza i, stoga sintezu kateholamina. Posledica toga je snižavanje nivoa kateholamina dopamina, adrenalina i noradrenalina u telu.
(IUPAC) ime | |||
---|---|---|---|
(2S)-2-amino- 3-(4-hidroksifenil)- 2-metilpropanoinska kiselina | |||
Klinički podaci | |||
Robne marke | Demser | ||
AHFS/Drugs.com | Potrošačka informacije o leku | ||
Identifikatori | |||
CAS broj | 672-87-7 | ||
ATC kod | C02KB01 | ||
PubChem[1][2] | 10123 | ||
DrugBank | DB00765 | ||
ChemSpider[3] | 390103 | ||
UNII | DOQ0J0TPF7 | ||
KEGG[4] | D00762 | ||
ChEMBL[5] | CHEMBL1200862 | ||
Hemijski podaci | |||
Formula | C10H13NO3 | ||
Mol. masa | 195,215 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakokinetički podaci | |||
Poluvreme eliminacije | 3,4–3,7 sata | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Clinical use
urediMetirozin je korišten u tretmanu feohromocitoma.[6]
On se relativno retko koristi kao lek i prvenstveno nalazi primenu u naučnim istraživanjima čiji je cilj utvrđivanje uticaja iscrpljivanja kateholamina na ponašanje.[7]
Reference
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (August 1982). „Alpha-methyltyrosine in the management of phaeochromocytoma”. Thorax 37 (8): 632–3. DOI:10.1136/thx.37.8.632. PMC 459390. PMID 7179194.
- ↑ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test. Psychopharmacology (Berlin). 2007 Jun;192(3):357-71. PMID 17318507