Tedatioksetin
(Preusmjereno sa stranice CVASBKDYSQKLSO-UHFFFAOYSA-N)
Tedatioksetin (Lu AA24530) je antidepresiv koji je u razvoju za tretman kliničke depresije (MDD).[5][6] Tedatioksetin deluje kao trostruki inhibitor preuzimanja (5-HT > NE > DA). On je isto tako antagonist na 5-HT2A, 5-HT2C, 5-HT3 i α1A-adrenergičkim receptorima.Greška u referenci: Nevaljana oznaka <ref>
; nevaljana imena, tj. ima ih previše[7][8][9][10]
(IUPAC) ime | |||
---|---|---|---|
4-{2-[(4-metilfenil)sulfanil]fenil}piperidin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 508233-95-2 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 9878913 | ||
ChemSpider[3] | 8054590 | ||
KEGG[4] | D10170 | ||
Hemijski podaci | |||
Formula | C18H21NS | ||
Mol. masa | 283,43 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Sinonimi | Lu AA24530; Lu-AA-24530 | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Investigational |
Vidi još uredi
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ „Pipeline”. Arhivirano iz originala na datum 2012-09-28. Pristupljeno 4. 10. 2012.
- ↑ „Search of: Lu AA24530 - List Results - ClinicalTrials.gov”.
- ↑ Stahl, Stephen M. (19. 5. 2008.). Depression and bipolar disorder: Stahl's essential psychopharmacology. Cambridge University Press. str. 206. ISBN 978-0-521-88663-5. Pristupljeno 22 November 2011.
- ↑ Stolerman, Ian P. (30. 8. 2010.). Encyclopedia of Psychopharmacology. Springer. str. 105. ISBN 978-3-540-68698-9. Pristupljeno 22 November 2011.
- ↑ „Lu AA24530 shows positive results in major depressive disorder phase II study - FierceBiotech”.
- ↑ „Future Treatments for Depression, Anxiety, Sleep Disorders, Psychosis, and ADHD -- Neurotransmitter.net”.
Literatura uredi
- Stolerman, Ian P. (30. 8. 2010.). Encyclopedia of Psychopharmacology. Springer. str. 105. ISBN 978-3-540-68698-9. Pristupljeno 22 November 2011.
- Stahl, Stephen M. (19. 5. 2008.). Depression and bipolar disorder: Stahl's essential psychopharmacology. Cambridge University Press. str. 206. ISBN 978-0-521-88663-5. Pristupljeno 22 November 2011.