Supstanca P

Supstanca P
Identifikacija
CAS registarski broj	33507-63-0
PubChem	36511
ChemSpider	33558
MeSH	Substance+P
ChEMBL	CHEMBL235363
InChI
	InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 ; Kod: ADNPLDHMAVUMIW-CUZNLEPHSA-N InChI=1/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1; Kod: ADNPLDHMAVUMIW-CUZNLEPHBU
Svojstva
Molekulska formula	C63H98N18O13S
Molarna masa	1347.63 g/mol
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Tahikinin, prekurzor 1
	Model supstance P
Identifikatori
Simbol	TAC1
Alt. simboli	TAC2, NKNA
Entrez	6863
HUGO	11517
OMIM	162320
RefSeq	NM_003182
UniProt	P20366
Drugi podaci
Lokus	Hromozom 7 q21-q22

U neuronauci supstanca P (SP) je neuropeptid: undekapeptid koji funkcioniše kao neurotransmiter i neuromodulator.^[5]^[6] Ovaj molekul pripada familiji tahikininskih neuropeptida. Supstanca P i njen blisko srodni neuropeptid neurokinin A (NKA) nastaju iz poliproteinskog prekurzora nakon diferencijalnog splajsovanja gena preprotahikinina A. Aminokiselinska sekvenca supstance P je^[7]^[8]:

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met

Supstanca P se oslobađa iz završetaka specifičnih senzornih nerava. Nađena je u mozgu i kičmenoj moždini, i učestvuje u inflamatornim procesima i senzaciji bola.

Otkriće

Supstancu P su originalno otkrili 1931 Ulf von Euler i Džon H. Gadum kao extrakt tkiva koji izaziva intestinalne kontrakcije in vitro.^[9] Njena distribucija u tkivu i biološka dejstva su detaljno ispitivana tokom decenija koje su sledele.^[5] NKA (prethodno poznata kao supstanca K ili neuromedin L) je izolovana iz svinjske kičmene moždine 1983, i ustanovljeno je da takođe stimuliše intestinalne kontrakcije.^[10]

Receptor

Endogeni receptor supstance P je neurokininski 1 receptor (NK1-receptor, NK1R).^[11] On pripada familiji tahikininskih receptora G protein-spregnutih receptora.^[12]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^5,0 ^5,1 Harrison S, Geppetti P (June 2001). „Substance p”. The International Journal of Biochemistry & Cell Biology 33 (6): 555–76. DOI:10.1016/S1357-2725(01)00031-0. PMID 11378438.
↑ Datar P, Srivastava S, Coutinho E, Govil G (2004). „Substance P: structure, function, and therapeutics”. Current topics in medicinal chemistry 4 (1): 75–103. DOI:10.2174/1568026043451636. PMID 14754378. Arhivirano iz originala na datum 2009-08-17. Pristupljeno 2021-08-12.
↑ Chang MM, Leeman SE, Niall HD (July 1971). „Amino-acid sequence of substance P”. Nature: New Biology 232 (29): 86–7.
↑ Leeman SE, Mroz EA (December 1974). „Substance P”. Life Sciences 15 (12): 2033–44. PMID 4613983.
↑ V Euler US, Gaddum JH (June 1931). „An unidentified depressor substance in certain tissue extracts”. The Journal of Physiology 72 (1): 74–87. PMC 1403098. PMID 16994201. ^{[mrtav link]}
↑ Panula P, Hadjiconstantinou M, Yang HY, Costa E (October 1983). „Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons”. The Journal of Neuroscience : the official journal of the Society for Neuroscience 3 (10): 2021–9. PMID 6194276.
↑ Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C (November 1991). „Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones”. Biochemistry 30 (44): 10640–6. DOI:10.1021/bi00108a006. PMID 1657150.
↑ Maggi CA (1995). „The mammalian tachykinin receptors”. Gen. Pharmacol. 26 (5): 911–44. DOI:10.1016/0306-3623(94)00292-U. PMID 7557266.

Vanjske veze

Portal Hemija

Russell J (14. 09. 2001.). „Neurochemical Substance P is Key to Understanding Pain Process”. Fibromyalgia Library. ProHealth.com. Pristupljeno 01. 11. 2008.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid11378438-5] 5,0 ^5,1 Harrison S, Geppetti P (June 2001). „Substance p”. The International Journal of Biochemistry & Cell Biology 33 (6): 555–76. DOI:10.1016/S1357-2725(01)00031-0. PMID 11378438.

[pmid14754378-6] Datar P, Srivastava S, Coutinho E, Govil G (2004). „Substance P: structure, function, and therapeutics”. Current topics in medicinal chemistry 4 (1): 75–103. DOI:10.2174/1568026043451636. PMID 14754378. Arhivirano iz originala na datum 2009-08-17. Pristupljeno 2021-08-12.

[pmid-7] Chang MM, Leeman SE, Niall HD (July 1971). „Amino-acid sequence of substance P”. Nature: New Biology 232 (29): 86–7.

[pmid4613983-8] Leeman SE, Mroz EA (December 1974). „Substance P”. Life Sciences 15 (12): 2033–44. PMID 4613983.

[pmid16994201-9] V Euler US, Gaddum JH (June 1931). „An unidentified depressor substance in certain tissue extracts”. The Journal of Physiology 72 (1): 74–87. PMC 1403098. PMID 16994201. ^{[mrtav link]}

[pmid6194276-10] Panula P, Hadjiconstantinou M, Yang HY, Costa E (October 1983). „Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons”. The Journal of Neuroscience : the official journal of the Society for Neuroscience 3 (10): 2021–9. PMID 6194276.

[pmid1657150-11] Gerard NP, Garraway LA, Eddy RL Jr, Shows TB, Iijima H, Paquet JL, Gerard C (November 1991). „Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones”. Biochemistry 30 (44): 10640–6. DOI:10.1021/bi00108a006. PMID 1657150.

[pmid7557266-12] Maggi CA (1995). „The mammalian tachykinin receptors”. Gen. Pharmacol. 26 (5): 911–44. DOI:10.1016/0306-3623(94)00292-U. PMID 7557266.

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