Eletriptan

Eletriptan
(IUPAC) ime
	(R)-3-[(-1-metilprolidin-2-il)metil]-5-(2-fenilsulfoniletil)- 1H-indol
Klinički podaci
Robne marke	Relpax
AHFS/Drugs.com	Monografija
MedlinePlus	a603029
Identifikatori
CAS broj	143322-58-1
ATC kod	N02CC06
PubChem	77993
DrugBank	DB00216
ChemSpider	70379
UNII	22QOO9B8KI
KEGG	D01973
ChEBI	CHEBI:50922
ChEMBL	CHEMBL1510
Hemijski podaci
Formula	C22H26N2O2S
Mol. masa	382,52 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-137T56T ; Key: PWVXXGRKLHYWKM-LJQANCHMSA-N
Farmakokinetički podaci
Bioraspoloživost	50%
Metabolizam	CYP3A4
Poluvreme eliminacije	4 sata
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status	℞ Prescription only
Način primene	oralnot

Eletriptan (Relpaks, Relert) je član druge generacije triptanski lekova namenjenih tretmanu migrenske glavobolje. On se korist kao blokiranje migrenskih napada koji su već u toku.

FDA je odobrila eletriptan 2002 za akutni tretman migrene kod odraslih.^[6] On je dostupan samo na recept u SAD-u k Kanadi. On nije namenjen za profilaktičku terapiju migrene ili za upotrebu u kontroli hemiplegične ili bazilarne migrene. Eletriptan je pokriven SAD patent 5545644^[6]^[7] and SAD patent 6110940;^[6]^[8] the FDA lists the patents as scheduled for expiration on December 26, 2016, and August 29, 2017, respectively.^[6]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^6,0 ^6,1 ^6,2 ^6,3 FDA AccessData entry for Eletriptan Hydrobromide, accessed March 10, 2010.
↑ SAD patent 5545644, John E. Macor & Martin J. Wythes, Indole Derivatives, August 13, 1996.
↑ SAD patent 6110940, Valerie Denise Harding, et al., Salts of an anti-migraine indole derivative, August 29, 2000.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

FDA label^{[mrtav link]}
Relpax Arhivirano 2010-12-19 na Wayback Machine-u
Medline Plus Drug Information for Eletriptan

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[accessdata-6] 6,0 ^6,1 ^6,2 ^6,3 FDA AccessData entry for Eletriptan Hydrobromide, accessed March 10, 2010.

[7] SAD patent 5545644, John E. Macor & Martin J. Wythes, Indole Derivatives, August 13, 1996.

[8] SAD patent 6110940, Valerie Denise Harding, et al., Salts of an anti-migraine indole derivative, August 29, 2000.

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