Ljudski serumski albumin

Ljudski serumski albumin je najzastupljeniji protein u ljudskoj krvnoj plazmi. On se formira u jetri. Albumin sačinjava oko polovine krvnog serumskog proteina. On je rastvoran i monomeran. Albuminom se transportuju hormoni, masne kiseline, i druga jedinjenja, puferuje pH, i održava osmotski pritisak, i vrši niz drugih funkcija.

Ljudski serumski albumin
PDB prikaz baziran na 1e7h.
Identifikatori
Simbol	ALB
Entrez	213
HUGO	399
OMIM	103600
PDB	1E7H
RefSeq	NM_000477
UniProt	P02768
Drugi podaci
Lokus	Hromozom 4 q13.3

Literatura

• Komatsu T, Nakagawa A, Curry S, et al. (2009). „The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O(2) and CO binding to iron protoporphyrin IX”. Org. Biomol. Chem. 7 (18): 3836–41. DOI:10.1039/b909794e. PMID 19707690. 
• Milojevic J, Raditsis A, Melacini G (2009). „Human Serum Albumin Inhibits Aβ Fibrillization through a "Monomer-Competitor" Mechanism”. Biophys. J. 97 (9): 2585–94. DOI:10.1016/j.bpj.2009.08.028. PMC 2770600. PMID 19883602. 
• Silva AM, Hider RC (2009). „Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation”. Biochim. Biophys. Acta 1794 (10): 1449–58. DOI:10.1016/j.bbapap.2009.06.003. PMID 19505594. 
• Otosu T, Nishimoto E, Yamashita S (2010). „Multiple conformational state of human serum albumin around single tryptophan residue at various pH revealed by time-resolved fluorescence spectroscopy”. J. Biochem. 147 (2): 191–200. DOI:10.1093/jb/mvp175. PMID 19884191. 
• Blindauer CA, Harvey I, Bunyan KE, et al. (2009). „Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin”. J. Biol. Chem. 284 (34): 23116–24. DOI:10.1074/jbc.M109.003459. PMC 2755717. PMID 19520864. 
• Juárez J, Lápez SG, Cambán A, et al. (2009). „Influence of electrostatic interactions on the fibrillation process of human serum albumin”. J Phys Chem B 113 (30): 10521–9. DOI:10.1021/jp902224d. PMID 19572666. 
• Fu BL, Guo ZJ, Tian JW, et al. (2009). „[Advanced glycation end products induce expression of PAI-1 in cultured human proximal tubular epithelial cells through NADPH oxidase dependent pathway]”. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 (8): 674–7. PMID 19664386. 
• Ascenzi P, di Masi A, Coletta M, et al. (2009). „Ibuprofen Impairs Allosterically Peroxynitrite Isomerization by Ferric Human Serum Heme-Albumin”. J. Biol. Chem. 284 (45): 31006–17. DOI:10.1074/jbc.M109.010736. PMC 2781501. PMID 19734142. 
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). „Defining the Human Deubiquitinating Enzyme Interaction Landscape”. Cell 138 (2): 389–403. DOI:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732. 
• Curry S (2002). „Beyond expansion: structural studies on the transport roles of human serum albumin”. Vox Sang. 83 Suppl 1: 315–9. PMID 12617161. 
• Guo S, Shi X, Yang F, et al. (2009). „Structural basis of transport of lysophospholipids by human serum albumin”. Biochem. J. 423 (1): 23–30. DOI:10.1042/BJ20090913. PMID 19601929. 
• de Jong PE, Gansevoort RT (2009). „Focus on microalbuminuria to improve cardiac and renal protection”. Nephron Clin Pract 111 (3): c204–10; discussion c211. DOI:10.1159/000201568. PMID 19212124. 
• Page TA, Kraut ND, Page PM, et al. (2009). „Dynamics of loop 1 of domain I in human serum albumin when dissolved in ionic liquids”. J Phys Chem B 113 (38): 12825–30. DOI:10.1021/jp904475v. PMID 19711930. 
• Roche M, Rondeau P, Singh NR, et al. (2008). „The antioxidant properties of serum albumin”. FEBS Lett. 582 (13): 1783–7. DOI:10.1016/j.febslet.2008.04.057. PMID 18474236. 
• Wyatt AR, Wilson MR (2010). „Identification of Human Plasma Proteins as Major Clients for the Extracellular Chaperone Clusterin”. J. Biol. Chem. 285 (6): 3532–9. DOI:10.1074/jbc.M109.079566. PMC 2823492. PMID 19996109. 
• Cui FL, Yan YH, Zhang QZ, et al. (2010). „A study on the interaction between 5-Methyluridine and human serum albumin using fluorescence quenching method and molecular modeling”. J Mol Model 16 (2): 255–62. DOI:10.1007/s00894-009-0548-4. PMID 19588173. 
• Caridi G, Dagnino M, Simundic AM, et al. (2010). „Albumin Benkovac (c.1175 A > G; p.Glu392Gly): a novel genetic variant of human serum albumin”. Transl Res 155 (3): 118–9. DOI:10.1016/j.trsl.2009.10.001. PMID 20171595. 
• Deeb O, Rosales-Hernández MC, Gámez-Castro C, et al. (2010). „Exploration of human serum albumin binding sites by docking and molecular dynamics flexible ligand-protein interactions”. Biopolymers 93 (2): 161–70. DOI:10.1002/bip.21314. PMID 19785033. 
• Karahan SC, Koramaz I, Altun G, et al. (2010). „Ischemia-modified albumin reduction after coronary bypass surgery is associated with the cardioprotective efficacy of cold-blood cardioplegia enriched with N-acetylcysteine: a preliminary study”. Eur Surg Res 44 (1): 30–6. DOI:10.1159/000262324. PMID 19955769. 
• Jin C, Lu L, Zhang RY, et al. (2009). „Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus”. Clin. Chim. Acta 408 (1–2): 45–9. DOI:10.1016/j.cca.2009.07.003. PMID 19615354. 

Spoljašnje veze

Ljudski serumski albumin na Wikimedijinoj ostavi

• Human serum albumin
• Human Albumin structure in the Protein data bank
• Human Albumin information in the Swis-Prot/TrEMBL database
• Human Serum Albumin Arhivirano 2006-04-24 na Wayback Machine-u on the Human Protein Reference Database Arhivirano 2006-04-24 na Wayback Machine-u