Iproklozid

Iproklozid
(IUPAC) ime
	2-(4-hlorofenoksi)-N'-izopropil-acetohidrazid
Klinički podaci
Identifikatori
CAS broj	3544-35-2
ATC kod	N06AF06
PubChem	19063
ChemSpider	17998
UNII	1II9D6CB3J
KEGG	D07338
ChEMBL	CHEMBL91238
Hemijski podaci
Formula	C11H15ClN2O2
Mol. masa	242,70 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C11H15ClN2O2/c1-8(2)13-14-11(15)7-16-10-5-3-9(12)4-6-10/h3-6,8,13H,7H2,1-2H3,(H,14,15) ; Key: GGECDTUJZOXAAR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Uncontrolled
Način primene	Oralno

Iproklozid (Sursum, Sinderezin) je ireverzibilni i selektivni inhibitor monoaminske oksidaze (MAOI) iz hidrazinske hemijske klase koji je korišten kao antidepresiv, ali je njegova primena prekinuta.^[6] Poznato je da ovaj lek može da uzrokuje hepatitis i bilo je najmanje tri smrtna slučaja uzrokovana njegovom upotrebom.^[7]^[8]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Suerinck A, Suerinck E. (1966). „[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]”. Journal de médecine de Lyon 47 (96): 573–586. PMID 5930723.
↑ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). „Iproclozide fulminant hepatitis. Possible role of enzyme induction.”. Gastroenterology. 75 (3): 492–496. PMID 680506.
↑ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. str. 455. ISBN 9780824708115.

Vidi još uredi

Hidrazin (antidepresiv)

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid5930723-6] Suerinck A, Suerinck E. (1966). „[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]”. Journal de médecine de Lyon 47 (96): 573–586. PMID 5930723.

[pmid680506-7] Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). „Iproclozide fulminant hepatitis. Possible role of enzyme induction.”. Gastroenterology. 75 (3): 492–496. PMID 680506.

[bookDrug-induced_liver_disease-8] Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. str. 455. ISBN 9780824708115.

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