Imiloksan

Imiloksan
(IUPAC) ime
	(RS)-2-(2,3-dihidro-1,4-benzodioksin-2-ilmetil)-1-etilimidazol
Klinički podaci
Identifikatori
CAS broj	81167-16-0
ATC kod	nije dodeljen
PubChem	133621
UNII	ZJ56PS1DWK
ChEMBL	CHEMBL578481
Hemijski podaci
Formula	C14H16N2O2
Mol. masa	244,289 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3 ; Key: UXABARREKCJULM-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Imiloksan je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni antagonist α_2B adrenergičkog receptora.^[4] On je bio koristan u određivanju dejstva pojedinačnih α₂ adrenergičkih tipova.^[5]^[6]

Hemija

Imidazolna porcija imiloksana se priprema reakcijom imidata sa dietil acetalom aminoacetaldehida. N-alkilacija imidazola sa etil jodidom daje imiloksan.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Michel AD, Loury DN, Whiting RL (March 1990). „Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist”. British Journal of Pharmacology 99 (3): 560–4. PMC 1917331. PMID 1970500.
↑ Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D (January 2007). „Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats”. European Journal of Pharmacology 554 (2–3): 205–11. DOI:10.1016/j.ejphar.2006.09.068. PMID 17109851.
↑ Romero TR, de Castro Perez A, de Francischi JN, Gama Duarte ID (April 2009). „Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine”. European Journal of Pharmacology 608 (1–3): 23–7. DOI:10.1016/j.ejphar.2009.02.019. PMID 19236861.
↑ Caroon, Joan M.; Clark, Robin D.; Kluge, Arthur F.; Olah, Ronald; Repke, David B.; Unger, Stefan H.; Michel, Anton D.; Whiting, Roger L. (1982). „Structure-activity relationships for 2-substituted imidazoles as .alpha.2-adrenoceptor antagonists”. Journal of Medicinal Chemistry 25 (6): 666–70. DOI:10.1021/jm00348a012. PMID 6124635.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid1970500-4] Michel AD, Loury DN, Whiting RL (March 1990). „Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist”. British Journal of Pharmacology 99 (3): 560–4. PMC 1917331. PMID 1970500.

[pmid17109851-5] Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D (January 2007). „Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats”. European Journal of Pharmacology 554 (2–3): 205–11. DOI:10.1016/j.ejphar.2006.09.068. PMID 17109851.

[pmid19236861-6] Romero TR, de Castro Perez A, de Francischi JN, Gama Duarte ID (April 2009). „Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine”. European Journal of Pharmacology 608 (1–3): 23–7. DOI:10.1016/j.ejphar.2009.02.019. PMID 19236861.

[7] Caroon, Joan M.; Clark, Robin D.; Kluge, Arthur F.; Olah, Ronald; Repke, David B.; Unger, Stefan H.; Michel, Anton D.; Whiting, Roger L. (1982). „Structure-activity relationships for 2-substituted imidazoles as .alpha.2-adrenoceptor antagonists”. Journal of Medicinal Chemistry 25 (6): 666–70. DOI:10.1021/jm00348a012. PMID 6124635.

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