Iproklozid
(Preusmjereno sa stranice GGECDTUJZOXAAR-UHFFFAOYSA-N)
Iproklozid (Sursum, Sinderezin) je ireverzibilni i selektivni inhibitor monoaminske oksidaze (MAOI) iz hidrazinske hemijske klase koji je korišten kao antidepresiv, ali je njegova primena prekinuta.[6] Poznato je da ovaj lek može da uzrokuje hepatitis i bilo je najmanje tri smrtna slučaja uzrokovana njegovom upotrebom.[7][8]
(IUPAC) ime | |||
---|---|---|---|
2-(4-hlorofenoksi)-N'-izopropil-acetohidrazid | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 3544-35-2 | ||
ATC kod | N06AF06 | ||
PubChem[1][2] | 19063 | ||
ChemSpider[3] | 17998 | ||
UNII | 1II9D6CB3J | ||
KEGG[4] | D07338 | ||
ChEMBL[5] | CHEMBL91238 | ||
Hemijski podaci | |||
Formula | C11H15ClN2O2 | ||
Mol. masa | 242,70 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Uncontrolled | ||
Način primene | Oralno |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Suerinck A, Suerinck E. (1966). „[Depressive states in a sanatorium milieu and monoamine oxidase inhibitors. (Therapeutic results by the combination of iproclozide and chlordiazepoxide). Apropos of 146 cases]”. Journal de médecine de Lyon 47 (96): 573–586. PMID 5930723.
- ↑ Pessayre D, de Saint-Louvent P, Degott C, Bernuau J, Rueff B, Benhamou JP. (1978). „Iproclozide fulminant hepatitis. Possible role of enzyme induction.”. Gastroenterology. 75 (3): 492–496. PMID 680506.
- ↑ Neil Kaplowitz, Laurie D. DeLeve (2003). Drug-induced liver disease. Informa Health Care. str. 455. ISBN 9780824708115.