LY-272,015
(Preusmjereno sa stranice GDAJGLDMCDMPIR-UHFFFAOYSA-N)
LY-272,015 je derivat beta-karbolina. Ovaj lek je razvila kompanija Eli Lili. On deluje kao potentan i selektivan antagonist serotoninskog 5-HT2B receptora. On pokazuje antihipertenzivna svojstva u životinjskim modelima,[3][4] a takođe se koristi u istraživanjima drugih funkcija 5-HT2B receptora.[5]
(IUPAC) ime | |||
---|---|---|---|
1-(3,4-dimetoksibenzil)-6-metil-2,3,4,9-tetrahidro-1H-β-karbolin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 172895-15-7 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 9929424 | ||
Hemijski podaci | |||
Formula | C21H24N2O2 | ||
Mol. masa | 336,426 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Sinonimi | LY-272,015; 1-[(3,4-Dimetoksifenil)metil]-2,3,4,9-tetrahidro-6-metil-1H-pirido[3,4-b]indol | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Literatura uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. American Journal of Physiology. 1999 Mar;276(3 Pt 2):H944-52. PMID 10070078
- ↑ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. Journal of Pharmacology and Experimental Therapeutics. 2002 Oct;303(1):179-87. PMID 12235249
- ↑ Günther S, Maroteaux L, Schwarzacher SW. Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro. Journal of Neurobiology. 2006 Aug;66(9):949-61. DOI:10.1002/neu.20253 PMID 16758492