Pseudoefedrin

Pseudoefedrin
(IUPAC) ime
	(S,S)-2-metilamino-1-fenilpropan-1-ol
Klinički podaci
Robne marke	Afrinol, Sudafed, Sinutab (UK)
AHFS/Drugs.com	Monografija
MedlinePlus	a682619
Identifikatori
CAS broj	90-82-4
ATC kod	R01BA02
PubChem	7028
DrugBank	DB00852
ChemSpider	6761
UNII	7CUC9DDI9F
KEGG	D08449
ChEBI	CHEBI:51209
ChEMBL	CHEMBL1590
Hemijski podaci
Formula	C10H15NO
Mol. masa	165,23
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1 ; Key: KWGRBVOPPLSCSI-WCBMZHEXSA-N
Farmakokinetički podaci
Bioraspoloživost	~100%
Metabolizam	hepatički (10–30%)
Poluvreme eliminacije	4,3–8 sata
Izlučivanje	43–96% renalno
Farmakoinformacioni podaci
Trudnoća	B2(AU) C(US)
Pravni status	Samo uz dozvolu apotekara (S3) (AU) ? (CA) P (UK) OTC (SAD)
Način primene	oralno

Pseudoefedrin je simpatomimetik iz hemijskih klasa fenetilamina i amfetamina. On se može koristiti kao nazalni/sinusni dekongestiv, a i kao stimulans.^[7]

Soli pseudoefedrin hidrohlorid i pseudoefedrin sulfat su prisutne u mnogim preparatima na slobodno, bilo kao jedini sastojak, ili u kombinaciji sa antihistaminicima, guaifenezinom, dekstrometorfanom, paracetamolom (acetaminofenom), ili NSAID (kao što je aspirin ili ibuprofen).

Hemija

Pseudoefedrin je dijastereoizomer efedrina i lako se redukuje u metamfetamin, ili oksiduje u metkatinon.

Dva para enantiomera: efedrin (gore) i pseudoefedrin (dole)

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ ^6,0 ^6,1 ^6,2 Laurence L Brunton, ur. (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th izd.). New York: McGraw-Hill Medical Publishing Division. ISBN 0-07-142280-3.
↑ Hunter Gillies, Wayne E. Derman, Timothy D. Noakes, Peter Smith, Alicia Evans, and Gary Gabriels (1996-12-01). „Pseudoephedrine is without ergogenic effects during prolonged exercise”. Journal of Applied Physiology 81: 2611-2617. Arhivirano iz originala na datum 2017-06-19. Pristupljeno 2013-09-29.

Povezano

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[goodman-gilman-6] 6,0 ^6,1 ^6,2 Laurence L Brunton, ur. (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11th izd.). New York: McGraw-Hill Medical Publishing Division. ISBN 0-07-142280-3.

[7] Hunter Gillies, Wayne E. Derman, Timothy D. Noakes, Peter Smith, Alicia Evans, and Gary Gabriels (1996-12-01). „Pseudoephedrine is without ergogenic effects during prolonged exercise”. Journal of Applied Physiology 81: 2611-2617. Arhivirano iz originala na datum 2017-06-19. Pristupljeno 2013-09-29.

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