Aldehid feredoksin oksidoreduktaza
Aldehid feredoksin oksidoreduktaza (EC 1.2.7.5, AOR) je enzim sa sistematskim imenom aldehid:feredoksin oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aldehid feredoksin oksidoreduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.7.5 | ||||||||
| CAS broj | 138066-90-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- aldehid +H2O + 2 oksidovani feredoksin karboksilat + 2 H+ + 2 redukovani feredoksin
Ovaj enzim je senzitivan na kiseonik. On sadrži volfram-molibdopterin i gvožđe-sumporne klastere. Ovaj enzim katalizuje oksidaciju aldehida (uključujući krotonaldehid, acetaldehid, formaldehid i gliceraldehid) do njihovih korespondirajućih kiselina. On ne oksiduje gliceraldehid 3-fosfat, cf. EC 1.2.7.6, gliceraldehid-3-fosfat dehidrogenaza (feredoksin). Ovaj enzim može da koristi feredoksin ili metil viologen, ali ne NAD(P)+ kao elektronski akceptor.
Reference
uredi- ↑ Mukund, S. and Adams, M.W.W. (1991). „The novel tungsten-iron-sulfur protein of the hyperthermophilic archaebacterium, Pyrococcus furiosus, is an aldehyde ferredoxin oxidoreductase - evidence for its participation in a unique glycolytic pathway”. J. Biol. Chem. 266: 14208-14216. PMID 1907273.
- ↑ Johnson, J.L., Rajagopalan, K.V., Mukund, S. and Adams, M.W.W. (1993). „Identification of molybdopterin as the organic-component of the tungsten cofactor in four enzymes from hyperthermophilic archaea”. J. Biol. Chem. 268: 4848-4852. PMID 8444863.
- ↑ Chan, M.K., Mukund, S., Kletzin, A., Adams, M.W.W. and Rees, D.C. (1995). „Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase”. Science 267: 1463-1469. PMID 7878465.
- ↑ Roy, R., Menon, A.L. and Adams, M.W.W. (2001). „Aldehyde oxidoreductases from Pyrococcus furiosus”. Methods Enzymol. 331: 132-144. PMID 11265456.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.