2-Aminotetralin
'2-Aminotetralin (2-AT, 1,2,3,4-tetrahidronaftalen-2-amin, THN) je stimulansni lek. Njegova hemijska struktura se sastoji od tetralinske grupe sa aminskim supstituentom.[5][6]
(IUPAC) ime | |||
---|---|---|---|
1,2,3,4-tetrahidronaftalen-2-amin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 2954-50-9 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 34677 | ||
ChemSpider[3] | 31912 | ||
ChEMBL[4] | CHEMBL30294 | ||
Hemijski podaci | |||
Formula | C10H13N | ||
Mol. masa | 147,217 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Nije kontrolisana supstanca | ||
Način primene | Oralno |
2-AT je krut analog fenilizobutilamina. On potpuno zamenjuje d-amfetamin u testovima diskriminacije na pacovima, mada ima jednu osminu potentnosti.[5] Pokazano je da inhibira ponovno preuzimanje serotonina i norepinefrina, te da verovatno indukuje njihovo otpuštanje.[7][8] Verovatno je da ima uticaja na dopamin jer potpuno zamenjuje d-amfetamin u studijama na glodarima.[5]
Hemijski derivati uredi
Postoji znatan broj derivata 2-aminotetralina, među kojima su:
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 5,0 5,1 5,2 Oberlender R, Nichols DE. (1991). „Structural variation and (+)-amphetamine-like discriminative stimulus properties.”. Pharmacol Biochem Behav. 38 (3): 581–586. DOI:10.1016/0091-3057(91)90017-V. PMID 2068194.
- ↑ Marley E, Stephenson JD (August 1971). „Actions of dexamphetamine and amphetamine-like amines in chickens with brain transections”. British Journal of Pharmacology 42 (4): 522–42. PMC 1665761. PMID 5116035.
- ↑ Bruinvels J (June 1971). „Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brain”. British Journal of Pharmacology 42 (2): 281–6. PMC 1667157. PMID 5091160.
- ↑ Bruinvels J, Kemper GC (September 1971). „Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat”. British Journal of Pharmacology 43 (1): 1–9. PMC 1665934. PMID 4257629.