Sinefrin

Sinefrin
(IUPAC) ime
	4-[1-hidroksi-2-(metilamino)etil]fenol
Klinički podaci
Identifikatori
CAS broj	94-07-5
ATC kod	C01CA08 S01GA06
PubChem	7172
ChemSpider	6904
UNII	PEG5DP7434
KEGG	D07148
ChEBI	CHEBI:29081
ChEMBL	CHEMBL33720
Hemijski podaci
Formula	C9H13NO2
Mol. masa	167,205 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3 ; Key: YRCWQPVGYLYSOX-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Sinefrin (oksedrin) je lek koji se koristi za gubljenje telesne težine. Njgova efektivenost je sporno pitanje. Uprkos tome on je zadobio znatnu popularnost kao alternativa efedrina, srodne supstance koji je zabranjena, ili ima ograničenu upotrebu u mnogim zemljama usled rizika od njene moguće upotrebe kao prekursora u proizvodnji metamfetamina. Sinefrin se ne koristi za proizvodnju amfetamina, i prirodni sinefrin je usled njegove fenolne grupe, nepodesan za takvu diversifikacija.

Po nekim tvrdnjama proizvodi koji sadrže sinefrin uzrokuju nepoželjne kardiovaskularne reakcije.^[6] Sinefrin se može dobiti iz nezrelog voća Citrus aurantium, relativno malog citrusnog drveta.

Dijetarni suplementi su generalno dostupni u dozama od 3–30 mg. Kao lek, on se dozira oralno ili putem parenteralne injekcije od 20–100 mg kao vazokonstriktor za hipotenzivne pacijente.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Jordan, S; Murty, M; Pilon, K (2004). „Products containing bitter orange or synephrine: Suspected cardiovascular adverse reactions”. CMAJ 171 (8): 993–4. PMID 15497209.
↑ Baselt, Randall C. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th izd.). Foster City, California: Biomedical Publications. str. 1471–2. ISBN 978-0-9626523-7-0.

Literatura

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Duenwald, Mary (6. 1. 2004.). „Slim Pickings: Looking Beyond Ephedra”. The New York Times. Pristupljeno 1. 8. 2012.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid15497209-6] Jordan, S; Murty, M; Pilon, K (2004). „Products containing bitter orange or synephrine: Suspected cardiovascular adverse reactions”. CMAJ 171 (8): 993–4. PMID 15497209.

[7] Baselt, Randall C. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th izd.). Foster City, California: Biomedical Publications. str. 1471–2. ISBN 978-0-9626523-7-0.

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