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PTK2 proteinska tirozinska kinaza 2 (PTK2, Fokalna adheziona kinaza, FAK), protein je koji je kod ljudi kodiran PTK2 genom.[2] PTK2 je fokalna proteinska kinaza koja učestvuje u ćelijskoj adheziji (vazivanje ćelija za njihovo okruženje) i procesu širenja ćelija (kretanju ćelija).[3] Poznato je da kad je FAK blokiran, ćelija raka dojke postaju u manjoj meri metastatične usled umanjene mobilnosti.[4]

Proteinska tirozinska kinaza 2

PDB prikaz C-terminalnog FAT domena baziran na 1k04[1].
Dostupne strukture
1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 2RA7, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU6, 4GU9, 4I4E, 4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 4NY0
Identifikatori
SimboliPTK2; FADK; FAK; FAK1; FRNK; PPP1R71; p125FAK; pp125FAK
Vanjski IDOMIM600758 MGI95481 HomoloGene7314 GeneCards: PTK2 Gene
EC broj2.7.10.2
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez574714083
EnsemblENSG00000169398ENSMUSG00000022607
UniProtQ05397P34152
Ref. Sekv. (iRNK)NM_001199649NM_001130409
Ref. Sekv. (protein)NP_001186578NP_001123881
Lokacija (UCSC)Chr 8:
141.67 - 142.01 Mb
Chr 15:
73.21 - 73.42 Mb
PubMed pretraga[1][2]

Interakcije uredi

PTK2 formira interakcije sa:

Vidi još uredi

Reference uredi

  1. Arold, S. T.; Hoellerer, M. K.; Noble, M. E. (2002). „The structural basis of localization and signaling by the focal adhesion targeting domain”. Structure (London, England : 1993) 10 (3): 319–327. DOI:10.1016/S0969-2126(02)00717-7. PMID 12005431.  edit
  2. André E, Becker-André M (January 1993). „Expression of an N-terminally truncated form of human focal adhesion kinase in brain”. Biochemical and Biophysical Research Communications 190 (1): 140–7. DOI:10.1006/bbrc.1993.1022. PMID 8422239. 
  3. Blackshaw, S. E.; Dow, J. Kamal; Lackie, J. M. (1999). The dictionary of cell and molecular biology (3rd izd.). San Diego: Academic Press. ISBN 0-12-432565-3. 
  4. Physorg:When cancer cells can't let go
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  21. Han DC, Guan JL (August 1999). „Association of focal adhesion kinase with Grb7 and its role in cell migration”. J. Biol. Chem. 274 (34): 24425-30. DOI:10.1074/jbc.274.34.24425. PMID 10446223. 
  22. Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD (May 2000). „FAK integrates growth-factor and integrin signals to promote cell migration”. Nat. Cell Biol. 2 (5): 249-56. DOI:10.1038/35010517. PMID 10806474. 
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  24. 24,0 24,1 Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V (November 1998). „Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src)”. J. Biol. Chem. 273 (48): 32244-53. DOI:10.1074/jbc.273.48.32244. PMID 9822703. 
  25. Zhu T, Goh EL, Lobie PE (April 1998). „Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription”. J. Biol. Chem. 273 (17): 10682-9. DOI:10.1074/jbc.273.17.10682. PMID 9553131. 
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  43. Zhang Z, Hernandez-Lagunas L, Horne WC, Baron R (August 1999). „Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase”. J. Biol. Chem. 274 (35): 25093-8. DOI:10.1074/jbc.274.35.25093. PMID 10455189. 
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  46. Hecker TP, Grammer JR, Gillespie GY, Stewart J, Gladson CL (May 2002). „Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples”. Cancer Res. 62 (9): 2699-707. PMID 11980671. 
  47. Relou IA, Bax LA, van Rijn HJ, Akkerman JW (January 2003). „Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein”. Biochem. J. 369 (Pt 2): 407-16. DOI:10.1042/BJ20020410. PMC 1223094. PMID 12387730. 
  48. Sada K, Minami Y, Yamamura H (September 1997). „Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak”. Eur. J. Biochem. 248 (3): 827–33. DOI:10.1111/j.1432-1033.1997.00827.x. PMID 9342235. 
  49. Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). „Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase”. Mol. Cell. Biol. 21 (16): 5332-45. DOI:10.1128/MCB.21.16.5332-5345.2001. PMC 87257. PMID 11463817. 
  50. Thomas SM, Hagel M, Turner CE (January 1999). „Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin”. J. Cell. Sci. 112 (2): 181-90. PMID 9858471. 
  51. Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (July 1995). „Interaction of focal adhesion kinase with cytoskeletal protein talin”. J. Biol. Chem. 270 (28): 16995–9. DOI:10.1074/jbc.270.28.16995. PMID 7622520. 
  52. Gan B, Yoo Y, Guan JL (December 2006). „Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth”. J. Biol. Chem. 281 (49): 37321-9. DOI:10.1074/jbc.M605241200. PMID 17043358. 

Literatura uredi

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