Kanbisol (Nabidroks), je sintetički kanabinoidni derivat koji je dimetilheptilni homolog 9-nor-9β-hidroksiheksahidrokanabinola (HHC). On je potentan agonist CB1 i CB2 receptora, sa afinitetom vezivanja od 0,1 nM na CB1 i 0,2 nM na CB2.[4] On prvenstveno nalazi primenu u naučnim istraživanjima, u studijama receptorskog vezivanja s ciljem određivanja strukture i funkcije kanabinoidnih receptora.[5][6][7] U pojedinim zemljama je kontrolisana supstanca zbog njegove potencijalne zloupotrebe kao kanabinomimetski lek.[8]
Kanbisol
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(IUPAC) ime
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(6aR,9R,10aR)-6,6-dimetil-3-(2-metiloktan-2-il)-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1,9-diol
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Klinički podaci
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Identifikatori
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CAS broj
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56689-43-1
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ATC kod
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nije dodeljen
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PubChem[1][2]
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41969
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ChemSpider[3]
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16736847
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UNII
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NZ1ZPC4WSF Y
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Hemijski podaci
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Formula
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C24H38O3
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Mol. masa
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374,555 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C24H38O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,17-19,25-26H,6-12,15H2,1-5H3/t17?,18-,19-/m0/s1 Y Key: UEKGZFCGRQYMRM-MNNMKWMVSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Rhee MH, et al. (September 1997). „Cannabinol derivatives: binding to cannabinoid receptors and inhibition of adenylylcyclase”. Journal of Medicinal Chemistry 40 (20): 3228–33. DOI:10.1021/jm970126f. PMID 9379442.
- ↑ Rhee MH, et al. (December 2000). „Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor”. Journal of Neurochemistry 75 (6): 2485–91. PMID 11080201.
- ↑ Rhee MH (September 2002). „Functional role of serine residues of transmembrane dopamin VII in signal transduction of CB2 cannabinoid receptor”. Journal of Veterinary Science 3 (3): 185–91. PMID 12514330.
- ↑ Zhang R, et al. (July 2005). „Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template”. Molecular Pharmacology 68 (1): 69–83. DOI:10.1124/mol.104.007823. PMID 15840841.
- ↑ The Misuse of Drugs Act 1971 (Amendment) Order 2009
Spoljašnje veze
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