HU-210 je sintetički kanabinoid koji je prvi put sintetisan 1988. iz (1R,5S)-mirtenol]]a[6][7][8][9] HU-210 je 100 do 800 puta potentniji od prirodnog THC iz kanabisa i ima duže vreme dejstva.[10] HU-210 je (–)-1,1-dimetilheptil analog 11-hidroksi- Δ8- tetrahidrokanabinola.
HU-210
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| (IUPAC) ime
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| (6aR,10aR)- 9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen- 1-ol
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| Klinički podaci
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| Identifikatori
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| CAS broj
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112830-95-2
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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9821569
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| ChemSpider[3]
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21106322
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| ChEMBL[4]
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CHEMBL70625  Y
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| Hemijski podaci
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| Formula
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C25H38O3
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| Mol. masa
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386,567 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h13-15,19-20,26-27H,6-12,16H2,1-5H3/t19-,20-/m0/s1 Y
Key: UEXRUIOOOVZHFZ-PMACEKPBSA-N Y |
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| Sinonimi
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1,1-Dimetilheptil- 11-hidroksi- tetrahidrokanabinol
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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Plan I kontrolisana supstanca u SAD[5]
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Drugi HU kanabinoidi
uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ „Controlled Substances”. Arhivirano iz originala na datum 2016-04-17. Pristupljeno 2014-04-05.
- ↑ Mechoulam, R., Lander, N., Breuer, A., Zahalka, J. Synthesis of the Individual, Pharmacologically Distinct, Enantiomers of a Tetrahydrocannabinol Derivative. Tetrahedron: Asymmetry. 1990. Vol 1, No 5. pp 315-318.
- ↑ Mechoulam, R., et al. (1988). „Enantiomeric cannabinoids: stereospecificity of psychotropic activity”. Experientia 44 (9): 762–764. DOI:10.1007/BF01959156. PMID 3416993.
- ↑ Little PJ, Compton DR, Mechoulam R, Martin BR. Stereochemical effects of 11-OH-Δ8-THC-dimethylheptyl in mice and dogs. Pharmacology, Biochemistry, and Behavior. 1989 Mar;32(3):661-666.
- ↑ Järbe, T.; Hiltunen, A.; Mechoulam, R. (1989). „Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons”. The Journal of Pharmacology and Experimental Therapeutics 250 (3): 1000–1005. PMID 2550611.
- ↑ Devane, W. A., et al. (1992). „A novel probe for the cannabinoid receptor”. Journal of Medical Chemistry 35 (11): 2065–2069. DOI:10.1021/jm00089a018. PMID 1317925.
