Metazolamid

Metazolamid
(IUPAC) ime
	N-[5-(aminosulfonil)-3-metil-1,3,4-tiadiazol-2(3H)-iliden]acetamid
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a601233
Identifikatori
CAS broj	554-57-4
ATC kod	S01EC05
PubChem	4100
DrugBank	DB00703
ChemSpider	3958
UNII	W733B0S9SD
KEGG	D00655
ChEMBL	CHEMBL19
Hemijski podaci
Formula	C5H8N4O3S2
Mol. masa	236,274 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4- ; Key: FLOSMHQXBMRNHR-DAXSKMNVSA-N
Sinonimi	N-(3-Metil-5-sulfamoil-3H-1,3,4-tiadiazol-2-iliden) etanamid
Farmakokinetički podaci
Vezivanje za proteine plazme	55%
Poluvreme eliminacije	14 sati
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status	℞-only (SAD)
Način primene	Oralno

Metazolamid (Neptazan) je inhibitor karbonatne dehidrataze.^[6]^[7]^[8]^[9]

References uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Iyer G, Bellantone R, Taft D (1999). „In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.”. J Pharmacokinet Biopharm 27 (1): 45–66. DOI:10.1023/A:1020630712388. PMID 10533697.
↑ RxList. „Neptazane”. Arhivirano iz originala na datum 2006-08-12. Pristupljeno 20. 8. 2006.
↑ Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). „Stevens–Johnson syndrome induced by methazolamide treatment.”. Arch Ophthalmol 115 (4): 550–3. PMID 9109770.
↑ Skorobohach B, Ward D, Hendrix D (2003). „Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.”. Am J Vet Res 64 (2): 183–7. DOI:10.2460/ajvr.2003.64.183. PMID 12602587.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Iyer G, Bellantone R, Taft D (1999). „In vitro characterization of the erythrocyte distribution of methazolamide: a model of erythrocyte transport and binding kinetics.”. J Pharmacokinet Biopharm 27 (1): 45–66. DOI:10.1023/A:1020630712388. PMID 10533697.

[7] RxList. „Neptazane”. Arhivirano iz originala na datum 2006-08-12. Pristupljeno 20. 8. 2006.

[8] Shirato S, Kagaya F, Suzuki Y, Joukou S (1997). „Stevens–Johnson syndrome induced by methazolamide treatment.”. Arch Ophthalmol 115 (4): 550–3. PMID 9109770.

[9] Skorobohach B, Ward D, Hendrix D (2003). „Effects of oral administration of methazolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.”. Am J Vet Res 64 (2): 183–7. DOI:10.2460/ajvr.2003.64.183. PMID 12602587.

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