Enprostil je sintetički prostaglandin koji je sličan sa dinoprostonom. Enprostil je veoma potentan inhibitor sekrecije želudačne HCl.[4]
Enprostil
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| (IUPAC) ime
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| Metil 7-[(1S,2S,3S)- 3-hidroksi-2-[(S,E)-3-hidroksi-4-fenoksibut-1-enil]-5-oksociklopentil]hepta-4,5-dienoat
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| Klinički podaci
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| AHFS/Drugs.com
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Internacionalno ime leka
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| Identifikatori
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| CAS broj
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73121-56-9
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| ATC kod
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A02BB02
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| PubChem[1][2]
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51744
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| UNII
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J4IP5Z9DAU  Y
|
| KEGG[3]
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D01891 Y
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| Hemijski podaci
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| Formula
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C23H28O6
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| Mol. masa
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400,46 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C23H28O6/c1-28-23(27)12-8-3-2-7-11-19-20(22(26)15-21(19)25)14-13-17(24)16-29-18-9-5-4-6-10-18/h3-7,9-10,13-14,17,19-20,22,24,26H,8,11-12,15-16H2,1H3/t2?,17-,19+,20+,22+/m1/s1 Y
Key: PTOJVMZPWPAXER-JRIPZDIHSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Roszkowski, AP; Garay, GL; Baker, S; Schuler, M; Carter, H (1986). „Gastric antisecretory and antiulcer properties of enprostil, (+/-)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta- 4,5,13(t)-trienoic acid methyl ester”. The Journal of Pharmacology and Experimental Therapeutics 239 (2): 382–9. PMID 3095537.
- Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T. i dr.. (2000). „Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines”. Scandinavian Journal of Immunology 52 (6): 570–5. DOI:10.1046/j.1365-3083.2000.00815.x. PMID 11119262.
- Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro i dr.. (1997). „Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients”. Digestive Diseases and Sciences 42 (8): 1741–6. DOI:10.1023/A:1018825902055. PMID 9286243.
- Ching, C. K.; Lam, S. K. (1995). „A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease”. Journal of Gastroenterology 30 (5): 607–14. DOI:10.1007/BF02367786. PMID 8574332.
