Deksanabinol (HU-211, ETS2101[4]) je sintetički kanabinoidni derivat koji je „neprirodni“ enantiomer potentnog kanabinoidnog agonista HU-210.[5] Za razliku od kanabinoidnih derivata, HU-211 ne deluje kao agonist kanabinoidnog receptora, nego kao NMDA antagonist.[6] On stoga ne proizvodi kanabisu slične efekte, ali je antikonvulsant i neuroprotektivan, te nalazi široku primenu u naučnim istraživanjima. On se takođe izučava za moguću primenu u tretmanu povrede glave, moždanog udara i kancera.[7][8][9] Klinička istraživanja su pokazala da je bezbedan.[10][11]
Deksanabinol
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(IUPAC) ime
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(6aS,10aS)-9-(Hidroksimetil)- 6,6-dimetil- 3-(2-metiloktan-2-il)- 6a,7,10,10a-tetrahidrobenzo [c]hromen-1-ol
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Klinički podaci
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Identifikatori
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CAS broj
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112924-45-5
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ATC kod
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nije dodeljen
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PubChem[1][2]
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107778
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ChemSpider[3]
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96934
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UNII
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R6VT8U5372 Y
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Hemijski podaci
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Formula
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C25H38O3
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Mol. masa
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386,567 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C25H38O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h10,14-15,19-20,26-27H,6-9,11-13,16H2,1-5H3/t19-,20-/m0/s1 Y Key: SSQJFGMEZBFMNV-PMACEKPBSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ e-therapeutics Clinical Development Pipeline
- ↑ Pop E (September 2000). „Nonpsychotropic synthetic cannabinoids”. Current Pharmaceutical Design 6 (13): 1347–60. DOI:10.2174/1381612003399446. PMID 10903397.
- ↑ Feigenbaum JJ, et al. (December 1989). „Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker”. Proceedings of the National Academy of Sciences of the United States of America 86 (23): 9584–7. DOI:10.1073/pnas.86.23.9584. PMC 298542. PMID 2556719.
- ↑ Biegon A; Joseph AB (August 1995). „Development of HU-211 as a neuroprotectant for ischemic brain damage”. Neurological Research 17 (4): 275–80. PMID 7477742.
- ↑ Darlington CL (October 2003). „Dexanabinol: a novel cannabinoid with neuroprotective properties”. IDrugs : the Investigational Drugs Journal 6 (10): 976–9. PMID 14534855.
- ↑ Vink R; Nimmo AJ (January 2009). „Multifunctional drugs for head injury”. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics 6 (1): 28–42. DOI:10.1016/j.nurt.2008.10.036. PMID 19110197.
- ↑ Maas AI, et al. (January 2006). „Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial”. Lancet Neurol 5 (1): 38–45. DOI:10.1016/S1474-4422(05)70253-2. PMID 16361021.
- ↑ University of California, San Diego "Synthetic Cannabinoid May Be Used as Brain Cancer Treatment". (28 September 2012) Laboratory Equipment. Retrieved 28 September 2012.
Spoljašnje veze
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