5-Metoksitriptamin
5-Metoksitriptamin (5-MT, meksamin) je derivat triptamina. On je blisko srodan neurotransmiterima serotoninu i melatoninu. Za 5-MT je pokazano da se prirodno javlja u telu u niskim nivoima.[6] On je proizvod dekarboksilacije melatonina u epifizi.[6]
(IUPAC) ime | |||
---|---|---|---|
2-(5-Methoxy-1H-indol-3-yl)ethanamine | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 608-07-1 | ||
ATC kod | ? | ||
PubChem[1][2] | 1833 | ||
ChemSpider[3] | 1767 | ||
KEGG[4] | C05659 | ||
ChEMBL[5] | CHEMBL8165 | ||
Hemijski podaci | |||
Formula | C11H14N2O | ||
Mol. masa | 190.242 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
5-MT deluje kao pun agonist 5-HT1, 5-HT2, 5-HT4, 5-HT6, i 5-HT7 receptora.[7][8][9][10][11][12][13] On nema afinitet za 5-HT3 receptor. Njegov afinitet za 5-HT1E receptor je veoma slab u poređenju sa drugim 5-HT1 receptorima.[10][14]
Povezano
urediРеференце
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ 6,0 6,1 Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ. (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).”. J Endocrinol. 118 (3): 389–397. DOI:10.1677/joe.0.1180389. PMID 2460575.
- ↑ Wu PH, Gurevich N, Carlen PL. (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.”. Neurosci Lett. 86 (1): 72–76. DOI:10.1016/0304-3940(88)90185-1. PMID 2966313.
- ↑ Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K. (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.”. Eur J Pharmacol. 323 (2-3): 235–240. DOI:10.1016/S0014-2999(97)00029-0. PMID 9128844.
- ↑ Amemiya N, Hatta S, Takemura H, Ohshika H. (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.”. Eur J Pharmacol. 318 (2-3): 403–409. DOI:10.1016/S0014-2999(96)00777-7. PMID 9016931.
- ↑ 10,0 10,1 Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE. (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9–16. PMID 2402303.
- ↑ Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ. (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.”. Neuropharmacology. 36 (4-5): 713–720. DOI:10.1016/S0028-3908(97)00019-1. PMID 9225298.
- ↑ Hemedah M, Coupar IM, Mitchelson FJ. (1999). „[3H-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.”]. Br J Pharmacol. 126 (1): 179–188. DOI:10.1038/sj.bjp.0702293. PMC 1565797. PMID 10051134.
- ↑ Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000.). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Pristupljeno 11. 4. 2008.
- ↑ Roth, Brian (2006). The serotonin receptors. Humana Press. str. 133. ISBN 9781588295682.
Литература
uredi- Roth, Brian (2006). The serotonin receptors. Humana Press. str. 133. ISBN 9781588295682.