WAY-213,613 je lek koji deluje kao inhibitor preuzimanja za podtip glutamatnog transportera EAAT2. On je selektivan u odnosu na druge podtipove glutamatnih transportera, i visoko je selektivan u odnosu na metabotropne i jonotropne glutamatne receptore.[3] It is used in scientific research into the function of the glutamate transporters.[4]
WAY-213,613
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| (IUPAC) ime
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| (2S)-2-amino-4-[4-(2-bromo-4,5-difluorofenoksi)anilino]-4-oksobutanoinska kiselina
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| Klinički podaci
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| Identifikatori
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| CAS broj
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868359-05-1
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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11531745
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| Hemijski podaci
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| Formula
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C16H13BrF2N2O4
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| Mol. masa
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415,186 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1  Y
Key: BNYDDAAZMBUFRG-ZDUSSCGKSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A et al. (2005). „Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2”. Molecular Pharmacology 68 (4): 974–82. DOI:10.1124/mol.105.012005. PMID 16014807.
- ↑ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). „Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells”. Neuroscience 161 (3): 794–805. DOI:10.1016/j.neuroscience.2009.04.017. PMID 19364521.
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