VU-0238429

VU-0238429
(IUPAC) ime
	1-(4-metoksibenzil)-5-(trifluorometoksi)indol-2,3-dion
Klinički podaci
Identifikatori
ATC kod	?
PubChem	42633508
ChemSpider	24606034
ChEMBL	CHEMBL466253
Hemijski podaci
Formula	C17H12F3NO4
Mol. masa	351,276 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 ; Key: CKLGZXFOLMHCMC-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

VU-0238429 je lek koji deluje kao selektivni pozitivni alosterni modulator za muskarinski acetilholinski receptor M₅. On je bio prvi selektivni ligand razvijen za M₅ podtip.^[5] VU-0238429 je strukturni derivat raznije otkrivenih M₁-selektivnih pozitivnih alosternih modulatora poput VU-0119498.^[6]^[7]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Bridges TM, Marlo JE, Niswender CM, et al. (June 2009). „Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins”. Journal of Medicinal Chemistry 52 (11): 3445–8. DOI:10.1021/jm900286j. PMID 19438238.
↑ Conn PJ, Jones CK, Lindsley CW (March 2009). „Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders”. Trends in Pharmacological Sciences 30 (3): 148–55. DOI:10.1016/j.tips.2008.12.002. PMC 2907736. PMID 19201489.
↑ Bridges T. M., Kennedy J. P., Hopkins C. R., Conn P. J., Lindsley C. W. (2010). „Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters 20 (19): 5617. DOI:10.1016/j.bmcl.2010.08.042.

Spoljašnje veze uredi

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid19438238-5] Bridges TM, Marlo JE, Niswender CM, et al. (June 2009). „Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins”. Journal of Medicinal Chemistry 52 (11): 3445–8. DOI:10.1021/jm900286j. PMID 19438238.

[pmid19201489-6] Conn PJ, Jones CK, Lindsley CW (March 2009). „Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders”. Trends in Pharmacological Sciences 30 (3): 148–55. DOI:10.1016/j.tips.2008.12.002. PMC 2907736. PMID 19201489.

[7] Bridges T. M., Kennedy J. P., Hopkins C. R., Conn P. J., Lindsley C. W. (2010). „Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators”. Bioorganic & Medicinal Chemistry Letters 20 (19): 5617. DOI:10.1016/j.bmcl.2010.08.042.

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