Uabajin je otrovni srčani glikozid.[6][7] Njegovo ime potiče od Somalske reči waabaayo, "otrvo strele". On se takođe naziva g-strofantin.

Uabajin
(IUPAC) ime
1β,3β,5β,11α,14,19-Heksahidroksikard-20(22)-enolid 3-(6-deoksi-α-L-manopiranozid)
ili
4-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-tetrahidroksi-10-
(hidroksimetil)-13-metil-3-((2R,3R,4R,5R,6S)-3,4,5-trihidroksi-6-metiltetrahidro-2H-
piran-2-iloksi)heksadekahidro-1H-ciklopenta[a]fenantren-17-il]furan-2(5H)-on
Klinički podaci
Robne marke Strodival
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 630-60-4
ATC kod C01AC01
PubChem[1][2] 439501
DrugBank DB01092
ChemSpider[3] 388599
UNII 5ACL011P69 DaY
KEGG[4] D00112 DaY
ChEBI CHEBI:472805 DaY
ChEMBL[5] CHEMBL447086 DaY
Hemijski podaci
Formula C29H44O12 
Mol. masa 584,652
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
k-Strofantin

Izvori

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Uabajin (g-strofantin) se formira u zrelom semenju afričke biljke Strophanthus gratus i kori Acokanthera ouabaio.

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  7. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

Povezano

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Spoljašnje veze

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