Olmesartan

Olmesartan medoksomil
(IUPAC) ime
	(5-metil-2-okso-2H-1,3-dioksol-4-il)metil 4-(2-hidroksipropan-2-il)-2-propil-1-({4-[2-(2H-1,2,3,4-tetrazol-5-il)fenil]fenil}metil)-1H-imidazol-5-karboksilat
Klinički podaci
Robne marke	Benicar, Olmetec, WinBP, Golme, Erastapex.
AHFS/Drugs.com	Monografija
MedlinePlus	a603006
Identifikatori
CAS broj	144689-63-4
ATC kod	C09CA08 ; C09DA08 (sa diureticima); C09DB02 (sa amlodipinom)
PubChem	130881
DrugBank	DB00275
ChemSpider	115748
UNII	6M97XTV3HD
KEGG	D01204
ChEMBL	CHEMBL1516
Hemijski podaci
Formula	C29H30N6O6
Mol. masa	558,585 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34) ; Key: UQGKUQLKSCSZGY-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	26%
Metabolizam	Hepatički (ne može se ukloniti hemodijalizom)
Poluvreme eliminacije	13 sata
Izlučivanje	Renalno 40%, bilijarno 60%
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Olmesartan medoksomil (Benicar u SAD, Olmetec u EU, Kanadi i Japanu, WinBP, Golme u Indiji, Erastapex u Egiptu) je antagonist angiotenzin II receptora koji se koristi za tretiranje visokog krvnog pritiska.

Indikacije

Olmesartan je indiciran za tretman hipertenzije. On se može koristiti pojedinačno ili u kombinaciji sa drugim antihipertenzivnim agensima.^[6] FDA je ustanovila da je korist od Benicara veća od potencijalnih rizika kad se koristi za tretiranje pacijenata sa visokim krvnim pritiskom.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ RxList Inc. (5. 7. 2007.). „Benicar (olmesartan medoxomil)”. RxList Inc.. Pristupljeno 22. 7. 2010.
↑ „FDA Alert: Benicar (olmesartan): Ongoing Safety Review”. Drugs.com. Pristupljeno 27. 6. 2013.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Benicar HCT from RXlist.com
Mayo Clinic Proceedings vol.87 Issue 8, pages 732-738

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[RxList-6] RxList Inc. (5. 7. 2007.). „Benicar (olmesartan medoxomil)”. RxList Inc.. Pristupljeno 22. 7. 2010.

[7] „FDA Alert: Benicar (olmesartan): Ongoing Safety Review”. Drugs.com. Pristupljeno 27. 6. 2013.

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