Talipeksol (B-HT920) je dopaminski agonist sa mogućom primenom kao antiparkinsonski agens.[4] On takođe deluje kao agonist α1-adrenergičkog i α2-adrenergičkog receptora.[5]
Talipeksol
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(IUPAC) ime
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6-alil-5,6,7,8-tetrahidro-4H-[1,3]tiazolo[4,5-d]azepin-2-amin
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Klinički podaci
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AHFS/Drugs.com
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Internacionalno ime leka
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Identifikatori
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ATC kod
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nije dodeljen
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PubChem[1][2]
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5374
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UNII
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7AM2J46Z1Y Y
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ChEMBL[3]
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CHEMBL1289023 Y
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Hemijski podaci
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Formula
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C10H15N3S
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Mol. masa
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209,31 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12) Y Key: DHSSDEDRBUKTQY-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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℞ Prescription only
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Način primene
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Oralno
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Kitamura Y, Kosaka T, Kakimura JI, et al. (December 1998). „Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells”. Mol. Pharmacol. 54 (6): 1046–54. PMID 9855633. [mrtav link]
- ↑ Van der Laan JW (February 1987). „Dopaminergic and alpha 1-adrenergic properties of B-HT920 revealed in morphine-dependent rats”. Pharmacology, Biochemistry, and Behavior 26 (2): 265–9. DOI:10.1016/0091-3057(87)90116-X. PMID 2883663.
Spoljašnje veze
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