Sunepitron
Sunepitron (CP-93,393) je kombinovani agonist 5-HT1A receptora i antagonist α2-adrenergičkog receptora.[6][7] On je bio u razvoju za tretiranje depresije i anksioznosti.[8] Dospeo je do faze III kliničkih ispitivanja pre nego što je razvoj prekinut.[7][8]
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 1[2-(pirimidin-2-il)oktahidro-2H-pirido[1,2-a]pirazin-7-il]metil}pirolidin-2,5-dion | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 148408-65-5 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 9799246 | ||
| ChemSpider[3] | 7975011 | ||
| UNII | 2GT50C8U60 
| ||
| KEGG[4] | D02569 | ||
| ChEMBL[5] | CHEMBL380369 | ||
| Hemijski podaci | |||
| Formula | C17H23N5O2 | ||
| Mol. masa | 329,40 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | Nije kontrolisana supstanca | ||
| Način primene | Oralno | ||
Sinteza uredi
Jedan od mogućih sintetičkih puteva je:[9]
Vidi još uredi
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Goodnick PJ (July 1999). „Psychopharmacology of depression in the next millennium”. CNS Spectrums 4 (7): 21-35. PMID 18438295.
- ↑ 7,0 7,1 Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4.
- ↑ 8,0 8,1 Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0.
- ↑ G.N. Bright, K.A. Desai, U.S. Patent 5,122,525 (1992).
Literatura uredi
- Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0.
- Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4.
- Kaplan, Eliot F.; Turkington, Carol (2001). Making the antidepressant decision: how to choose the right treatment option for you and your loved ones. Chicago, Ill: Contemporary Books. ISBN 0-7373-0417-0.
- Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4.
