Sulfoacetaldehid dehidrogenaza
Sulfoacetaldehid dehidrogenaza (EC 1.2.1.73, SafD) je enzim sa sistematskim imenom 2-sulfoacetaldehid:NAD+ oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sulfoacetaldehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.73 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-sulfoacetaldehid +H2O + NAD+ sulfoacetat + NADH + 2 H+
Ova reakcija je deo bakterijskog puta koji koristi amino grupu taurina kao jedini izvor azota za rast. Pri fiziološkim koncentracijama, NAD+ ne može da bude zamenjen sa NADP+. Ovaj enzim je specifičan za sulfoacetaldehid, dok formaldehid, acetaldehid, betain aldehid, propanal, gliceraldehid, fosfonoacetaldehid, glioksilat, glikolaldehid i 2-oksobutirat nisu supstrati.
Reference uredi
- ↑ Krejčík, Z., Denger, K., Weinitschke, S., Hollemeyer, K., Pačes, V., Cook, A.M. and Smits, T.H.M. (2008). „Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase”. Arch. Microbiol. 190: 159-168. PMID 18506422.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.