SKF-77,434 je lek koji deluje kao selektivan parcijalni agonist dopaminskog D1 receptora. On ima stimulansne i anoreksične efekte. Za razliku od drugih D1 agonista sa većom efikasnošću poput SKF-81,297 i 6-Br-APB, SKF-77,434 ne održava samoadministraciju u životinjskim studijama, te je bio ispitivan kao potencijalni treatman za kokainsku adikciju.[3][4][5][6]
SKF-77,434
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(IUPAC) ime
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3-alil-1-fenil-1,2,4,5-tetrahidro-3-benzazepin-7,8-diol
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Klinički podaci
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Identifikatori
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CAS broj
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104422-04-0
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ATC kod
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?
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PubChem[1][2]
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1241
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Hemijski podaci
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Formula
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C19H21NO2
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Mol. masa
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295,375 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2 Y Key: QBUVZVXIRYFENV-UHFFFAOYSA-N Y |
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Grech D. M., Spealman R. D., Bergman J. (1996). „Self-administration of D1 receptor agonists by squirrel monkeys”. Psychopharmacology 125 (2): 97–104. DOI:10.1007/BF02249407. PMID 8783382.
- ↑ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). „Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434”. The Journal of pharmacology and experimental therapeutics 293 (3): 1017–1026. PMID 10869406.
- ↑ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L (1997). „The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys”. The Journal of pharmacology and experimental therapeutics 283 (1): 29–38. PMID 9336305.
- ↑ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). „Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys”. Psychopharmacology 157 (2): 208–216. DOI:10.1007/s002130100779. PMID 11594448.
Spoljašnje veze
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