SDZ SER-082 je lek koji deluje kao mešoviti antagonist za 5-HT2B i 5-HT2C serotoninske receptore, sa dobrom selektivnošću za druge tipove serotoninskog receptora i malom preferencijom za 5-HT2C u odnosu na 5-HT2B.[3] On je korišten u životinjskim studijama uticaja dejstva različitih 5-HT2 podtipova,[4][5][6] i kako oni utiču na efekte drugih lekova poput kokaina.[7][8][9]
SDZ SER-082
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| (IUPAC) ime
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| (+)-cis 4,5,7a,8,9,10,11,11a-oktahidro-7H-10-metilindolo[1,7-bc][2,6]-naftiridin
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| Klinički podaci
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| Identifikatori
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| CAS broj
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141474-54-6
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| ATC kod
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nije dodeljen
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| PubChem[1][2]
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9859407
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| Hemijski podaci
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| Formula
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C15H20N2
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| Mol. masa
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228,332 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
|---|
InChI=1S/C15H20N2/c1-16-7-5-12-9-17-8-6-11-3-2-4-13(15(11)17)14(12)10-16/h2-4,12,14H,5-10H2,1H3  Y
Key: YASBOGFWAMXINH-UHFFFAOYSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. DOI:10.1021/jm00001a007
- ↑ Mora PO, Netto CF, Graeff FG (December 1997). „Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze”. Pharmacology, Biochemistry, and Behavior 58 (4): 1051–7. DOI:10.1016/S0091-3057(97)00057-9. PMID 9408213.
- ↑ Dave KD, Harvey JA, Aloyo VJ (May 2002). „A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation”. Pharmacology, Biochemistry, and Behavior 72 (1-2): 371–8. DOI:10.1016/S0091-3057(01)00767-5. PMID 11900808.
- ↑ Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). „Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat”. Pharmacology, Biochemistry, and Behavior 90 (4): 632–9. DOI:10.1016/j.pbb.2008.05.006. PMID 18572227.
- ↑ Filip M, Bubar MJ, Cunningham KA (September 2004). „Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses”. The Journal of Pharmacology and Experimental Therapeutics 310 (3): 1246–54. DOI:10.1124/jpet.104.068841. PMID 15131246.
- ↑ Filip M (2005). „Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats”. Pharmacological Reports : PR 57 (1): 35–46. PMID 15849375.
- ↑ Filip M, Bubar MJ, Cunningham KA (January 2006). „Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats”. Psychopharmacology 183 (4): 482–9. DOI:10.1007/s00213-005-0197-y. PMID 16261316.
