Katehol O-metiltransferaza
(Preusmjereno sa stranice S-COMT (soluble form of catechol-O-methyltransferase))
Katehol O-metiltransferaza (EC 2.1.1.6, COMT I, COMT II, S-COMT, rastvorna forma katehol-O-metiltransferaze, MB-COMT, membranska forma katehol-O-metiltransferaze, kateholna metiltransferaza, kateholaminska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:katehol O-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katehol O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.1.1.6 | ||||||||
| CAS broj | 9012-25-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enzim sisara deluje brže na kateholamine kao što je adrenalin ili noradrenalin nego na katehole.
Reference
uredi- ↑ Axelrod, J. and Tomchick, R. (1958). „Enzymatic O-methylation of epinephrine and other catechols”. J. Biol. Chem. 233: 702-705. PMID 13575440.
- ↑ Gulliver, P.A. and Tipton, K.F. (1979). „The purification and properties of pig brain catechol-O-methyltransferase”. J. Neurochem. 32: 1525-1529. PMID 438821.
- ↑ Huh, M.M.O. and Friedhof, A.J. (1979). „Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization”. J. Biol. Chem. 254: 299-308. PMID 762061.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.