Pronethalol (Alderlin, Netalid) je bio klinički kandidat koji deluje kao neselektivni beta blokator. On nije dospeo do kliničkih istraživanja usled karcinogenosti na miševima, koja se smatra da je rezultat formiranja karcinogenih naftalen epoksidnih metabolita.[4]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Stapleton MP (1997). „Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology”. Tex Heart Inst J 24 (4): 336–42. PMC 325477. PMID 9456487.
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