Neurotenzinski receptori su GPCR transmembranski receptori koji vezuju neurotransmiter neurotenzin.[1][2] Dva od ovih receptora su kodirana genima NTSR1 i NTSR2, i sadrže sedam transmembranskih heliksa. Treći receptor poseduje jedan transmembranski domen i kodiran je SORT1 genom.
- Peptidni
- Ne-peptidni
- Parcijalni agonisti izvedeni iz SR-48692[4]
Antagonisti
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Literatura
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- ↑ Vincent JP, Mazella J, Kitabgi P (1999). „Neurotensin and neurotensin receptors”. Trends Pharmacol. Sci. 20 (7): 302–9. DOI:10.1016/S0165-6147(99)01357-7. PMID 10390649.
- ↑ Pelaprat D (2006). „Interactions between neurotensin receptors and G proteins”. Peptides 27 (10): 2476–87. DOI:10.1016/j.peptides.2006.04.027. PMID 16919370.
- ↑ Yamauchi R, Usui H, Yunden J, Takenaka Y, Tani F, Yoshikawa M (April 2003). „Characterization of beta-lactotensin, a bioactive peptide derived from bovine beta-lactoglobulin, as a neurotensin agonist”. Bioscience, Biotechnology, and Biochemistry 67 (4): 940–3. PMID 12784648.
- ↑ Thomas JB, Navarro H, Warner KR, Gilmour B (March 2009). „The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay”. Bioorganic & Medicinal Chemistry Letters 19 (5): 1438–41. DOI:10.1016/j.bmcl.2009.01.024. PMID 19195889.
- ↑ Bredeloux P, Costentin J, Dubuc I (December 2006). „Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice”. Behavioural Brain Research 175 (2): 399–407. DOI:10.1016/j.bbr.2006.09.016. PMID 17074405.
- ↑ Ferraro L, Tomasini MC, Mazza R, Fuxe K, Fournier J, Tanganelli S, Antonelli T (August 2008). „Neurotensin receptors as modulators of glutamatergic transmission”. Brain Research Reviews 58 (2): 365–73. DOI:10.1016/j.brainresrev.2007.11.001. PMID 18096238.
Spoljašnje veze
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