Tebaniklin
(Preusmjereno sa stranice MKTAGSRKQIGEBH-SSDOTTSWSA-N)
Tebaniklin (Ebanicline, ABT-594) je lek koji je razvilo preduzeće Abbott. On deluje kao parcijalni agonist neuronskih nikotinskih acetilholinskih receptora. Tebaniklin se vezuje za α3β4 i α4β2 receptore.[3] Ovaj lek je razvijen kao manje toksični analog epibatidina, koji ima oko 200x jače analgetskog dejstvo od morfina, ali je veoma toksičan.[4][5]
(IUPAC) ime | |||
---|---|---|---|
5-([(2R)-Azetidin-2-il]metoksi)-2-hloropiridin | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 198283-73-7 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 3075702 | ||
UNII | 9KX8NKV538 | ||
Hemijski podaci | |||
Formula | C9H11ClN2O | ||
Mol. masa | 198,649 | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Jain, K. K. (2004). „Modulators of nicotinic acetylcholine receptors as analgesics”. Current opinion in investigational drugs (London, England : 2000) 5 (1): 76–81. PMID 14983978.
- ↑ Bannon, A. W.; Decker, M. W.; Holladay, M. W.; Curzon, P.; Donnelly-Roberts, D.; Puttfarcken, P. S.; Bitner, R. S.; Diaz, A. i dr.. (1998). „Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors”. Science 279 (5347): 77–81. Bibcode 1998Sci...279...77B. DOI:10.1126/science.279.5347.77. PMID 9417028.
- ↑ Holladay, M.; Wasicak, J.; Lin, N.; He, Y.; Ryther, K.; Bannon, A.; Buckley, M.; Kim, D. i dr.. (1998). „Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors”. Journal of Medicinal Chemistry 41 (4): 407–412. DOI:10.1021/jm9706224. PMID 9484491.