Natrijum butirat

Natrijum butirat
	Natrijum butanoat
Drugi nazivi	Natrijum butirat
Identifikacija
CAS registarski broj	156-54-7
PubChem	5222465
ChEMBL	CHEMBL62381
Jmol-3D slike	Slika 1
SMILES
	CCCC(=O)[O-].[Na+]
InChI
	InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1 ; Kod: MFBOGIVSZKQAPD-UHFFFAOYSA-M InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
Svojstva
Molekulska formula	C4H7NaO2
Molarna masa	110.09 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Natrijum butirat je jedinjenje sa formulom Na(C₃H₇COO). Ono je natrijumova so buterne kiseline. Ovo jedinjenje deluje na kulture ćelija sisara na više načina, kao što su inhibicija proliferacija, indukcija diferencijacije, i indukcija i represija izražavanja gena.^[4] Usled toga ono ima širok spektar laboratorijske primene. Butiratni tretmani ćelija dovode do histonske hiperacetilacije. Butirat inhibira HDAC dejstvo.^[5] Butirat je bio esencijalan u određivanju uloge histonske acetilacije u strukturi i funkciji hromatina. Procenjuje se da inhibicija HDAC dejstva utiče na izražavanje samo 2% gena sisara.^[6]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Kruh, Jacques (1981). „Effects of sodium butyrate, a new pharmacological agent, on cells in culture”. Molecular and Cellular Biochemistry 42 (2): 65–82. DOI:10.1007/BF00222695. PMID 6174854.
↑ Candido, E; Reeves, Raymond; Davie, James R. (1978). „Sodium butyrate inhibits histone deacetylation in cultured cells”. Cell 14 (1): 105–13. DOI:10.1016/0092-8674(78)90305-7. PMID 667927.
↑ Davie, James R. (2003). „Inhibition of Histone Deacetylase Activity by Butyrate”. The Journal of Nutrition 133 (7 Suppl): 2485S–2493S. PMID 12840228.

Literatura uredi

Govindarajan, Nambirajan; Agis-Balboa, Roberto Carlos; Walter, Jonas; Sananbenesi, Farahnaz; Fischer, André (2011). „Sodium Butyrate Improves Memory Function in an Alzheimer's Disease Mouse Model When Administered at an Advanced Stage of Disease Progression”. Journal of Alzheimer's Disease 26 (1): 187–97. DOI:10.3233/JAD-2011-110080. PMID 21593570.

Spoljašnje veze uredi

Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Kruh-4] Kruh, Jacques (1981). „Effects of sodium butyrate, a new pharmacological agent, on cells in culture”. Molecular and Cellular Biochemistry 42 (2): 65–82. DOI:10.1007/BF00222695. PMID 6174854.

[Candid-5] Candido, E; Reeves, Raymond; Davie, James R. (1978). „Sodium butyrate inhibits histone deacetylation in cultured cells”. Cell 14 (1): 105–13. DOI:10.1016/0092-8674(78)90305-7. PMID 667927.

[6] Davie, James R. (2003). „Inhibition of Histone Deacetylase Activity by Butyrate”. The Journal of Nutrition 133 (7 Suppl): 2485S–2493S. PMID 12840228.

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