Lu AA-33810

Lu AA-33810
(IUPAC) ime
	N-[(trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl)methyl]methanesulfonamide
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	22254068
Hemijski podaci
Formula	C19H25N3O2S3
Mol. masa	423.615 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22) ; Key: UWSBTSAJZMIHBL-UHFFFAOYSA-N
Sinonimi	Lu AA-33810
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Lu AA-33810 je potentan i visoko selektivan antagonist neuropeptid Y receptora Y₅, sa Ki vrednošću od 1.5 nM. On je 3300x selektivniji za ovaj receptor nego za Y₁, Y₂ i Y₄ receptore. U životinjskim studijama on proizvodi anoreksne, antidepresantne i anksiolitske efekte. Dalja istraživanja se sprovode s ciljem njegovog njegove primene kao potencijalnog leka za poremećaje ishrane.^[3] Ovaj lek je razvila kompanija Lundbeck.

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). „The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity”]. The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. DOI:10.1124/jpet.108.144634. PMID 19098165.

Vanjske veze

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid19098165-3] Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). „The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity”]. The Journal of Pharmacology and Experimental Therapeutics 328 (3): 900–11. DOI:10.1124/jpet.108.144634. PMID 19098165.

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