DPI-3290
(Preusmjereno sa stranice LZXRQLIIMYJZDA-KERYWQKISA-N)
DPI-3290 je lek koji se koristi u naučnim istraživanjima. On je potentan analgetik,[3] koji zaziva neznatnu respiratornu depresiju.[4]
(IUPAC) ime | |||
---|---|---|---|
(+)-3-((αR)-α-((2S,5R)-4-Alil-2,5-dimetil-1-piperazinil)-3-hidroksibenzil)-N-(3-fluorofenil)-N-metilbenzamid | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 5242141 | ||
Hemijski podaci | |||
Formula | C30H34FN3O2 | ||
Mol. masa | 487.607 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
DPI-3290 deluje kao agonist μ- i δ-opioidnog receptora, sa IC50 vrednošću od 6.2 nM na μ i 1.0 nM na δ.[5]
Literatura
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Gengo, PJ; Pettit, HO; O'Neill, SJ; Wei, K; McNutt, R; Bishop, MJ; Chang, KJ (2003). „DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. I. A mixed opioid agonist with potent antinociceptive activity”. The Journal of pharmacology and experimental therapeutics 307 (3): 1221–6. DOI:10.1124/jpet.103.054361. PMID 14534368.
- ↑ Gengo, PJ; Pettit, HO; O'Neill, SJ; Su, YF; McNutt, R; Chang, KJ (2003). „DPI-3290 (+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function”. The Journal of pharmacology and experimental therapeutics 307 (3): 1227–33. DOI:10.1124/jpet.103.054429. PMID 14534367.
- ↑ Ananthan S. Opioid ligands with mixed mi/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. DOI 10.1208/aapsj080114 PMID 16584118