LMTK2
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Serin/treoninska proteinska kinaza LMTK2, takođe poznata kao Lemur tirozinska kinaza 2 (LMTK2), enzim je koji je kod ljudi kodiran LMTK2 genom.[1][2]
| Lemur tirozinska kinaza 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | LMTK2; AATYK2; BREK; KPI-2; KPI2; LMR2; PPP1R100; cprk | ||||||||||
| Vanjski ID | OMIM: 610989 MGI: 3036247 HomoloGene: 8948 GeneCards: LMTK2 Gene | ||||||||||
| EC broj | 2.7.11.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 22853 | 231876 | |||||||||
| Ensembl | ENSG00000164715 | ENSMUSG00000038970 | |||||||||
| UniProt | Q8IWU2 | Q3TYD6 | |||||||||
| Ref. Sekv. (iRNK) | NM_014916 | NM_001081109 | |||||||||
| Ref. Sekv. (protein) | NP_055731 | NP_001074578 | |||||||||
| Lokacija (UCSC) | Chr 7: 97.74 - 97.84 Mb | Chr 5: 144.1 - 144.19 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija uredi
LMTK2 enzim pripada familiji proteinskih tirozinskih kinaza. On sadrži N-terminusne transmembranske heliksae i dug C-terminusni citoplasmatični rep sa serin/treonin/tirozinskom kinaznom aktivnošću. Ovaj protein formira interakcije sa nekoliko drugih proteina, kao što su inhibitor-2 (Inh2), protein fosfataza-1 (PP1C), p35, i miozin VI. On fosforiliše druge proteine, i biva fosforilisan posredstvom ciklin zavisne kinaze 5 (cdk5)/p35 kompleksa. Ovaj protein učestvuje u signalizaciji nervnog faktora rasta (NGF)-TrkA, kao i u endozomnoj membranskoj razmeni. Studije na miševima sugerišu da ovaj protein ima esencijalnu ulogu u spermatogenizi.[2]
Interakcije uredi
LMTK2 formira interakcije sa PPP1CA,[3] ciklin zavisnom kinazom[4] i PPP1R2.[3]
Reference uredi
- ↑ Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). „Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling”. Genes Cells 9 (3): 219–32. DOI:10.1111/j.1356-9597.2004.00714.x. PMID 15005709.
- ↑ 2,0 2,1 „Entrez Gene: LMTK2 lemur tyrosine kinase 2”.
- ↑ 3,0 3,1 Wang, Hong; Brautigan David L (Dec 2002). „A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2”. J. Biol. Chem. (United States) 277 (51): 49605–12. DOI:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
- ↑ Kesavapany, Sashi; Lau Kwok-Fai; Ackerley Steven; Banner Steven J; Shemilt Stephen J A; Cooper Jonathan D; Leigh P Nigel; Shaw Christopher E i dr.. (Jun 2003). „Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase”. J. Neurosci. (United States) 23 (12): 4975–83. PMID 12832520.
Literatura uredi
- Eeles RA, Kote-Jarai Z, Giles GG, et al. (2008). „Multiple newly identified loci associated with prostate cancer susceptibility.”. Nat. Genet. 40 (3): 316–21. DOI:10.1038/ng.90. PMID 18264097.
- Chibalina MV, Seaman MN, Miller CC, et al. (2008). „Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.”. J. Cell. Sci. 120 (Pt 24): 4278–88. DOI:10.1242/jcs.014217. PMC 2621362. PMID 18029400.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983.
- Wang H, Brautigan DL (2007). „Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase.”. Mol. Cell Proteomics 5 (11): 2124–30. DOI:10.1074/mcp.M600188-MCP200. PMID 16887929.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- Kesavapany S, Lau KF, Ackerley S, et al. (2003). „Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.”. J. Neurosci. 23 (12): 4975–83. PMID 12832520.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Wang H, Brautigan DL (2003). „A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.”. J. Biol. Chem. 277 (51): 49605–12. DOI:10.1074/jbc.M209335200. PMID 12393858.
- Kikuno R, Nagase T, Ishikawa K, et al. (1999). „Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”. DNA Res. 6 (3): 197–205. DOI:10.1093/dnares/6.3.197. PMID 10470851.