L-lizin oksidaza
L-lizin oksidaza (EC 1.4.3.14, L-lizinska alfa-oksidaza, L-lizil-alfa-oksidaza) je enzim sa sistematskim imenom L-lizin:kiseonik 2-oksidoreduktaza (deaminacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| L-lizin oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.14 | ||||||||
| CAS broj | 70132-14-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-lizin + O2 + H2O 6-amino-2-oksoheksanoat + NH3 +H2O2
Ovaj enzim takođe deluje, mada sporo, na L-ornitin, L-fenilalanin, L-arginin i L-histidin.
Reference uredi
- ↑ Kusakabe, H., Kodama, K., Kuninaka, A., Yoshino, H., Misono, H. and Soda, K. (1980). „A new antitumor enzyme, L-lysine α-oxidase from Trichoderma viride. Purification and enzymological properties”. J. Biol. Chem. 255: 976-981. PMID 6101334.
- ↑ Lukasheva, E.V. and Berezov, T.T. (2002). „L-Lysine α-oxidase: physicochemical and biological properties”. Biochemistry (Mosc) 67: 1152-1158. PMID 12460113.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.