Otvori glavni meni

Kodein ili 3-metilmorfin (prirodni izomer od metil morfina) je opijat koji se koristi u medicini kao analgetik i antidiuretik.[6] Kodein je drugi alkaloid po dominantnosti u opijumu (do 3 odsto); mnogo više preovladava u iranskom maku (Papaver bractreatum). Smatra se drogom srednje klase.

Kodein
(IUPAC) ime
(5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
Klinički podaci
Identifikatori
CAS broj 76-57-3
ATC kod R05DA04 N02AA59
PubChem[1][2] 5284371
DrugBank APRD00120
ChemSpider[3] 4447447
ChEMBL[4] CHEMBL485 YesY
Hemijski podaci
Formula C18H21NO3 
Mol. masa 299.364 g/mol
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost ~90% Oralno
Metabolizam Hepatički, putem CYP2D6 (citohroma P450 2D6)[5]
Poluvreme eliminacije 2.5–3 h
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Droga (S8) (AU) Schedule I (CA) ? (UK) Schedule II (SAD)
Opojna droga nisko - umereno
Način primene oralno, intra-rektalno, supkutano, intramaskularno

Kodein se koristi za lečenje bolova, kao i za oslobađanje od kašlja.

IzvoriUredi

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. PMID 20331846. doi:10.1186/1758-2946-2-3.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. PMID 21948594. doi:10.1093/nar/gkr777.  edit
  5. Shen H, He MM, Liu H et al. (August 2007). "Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17". Drug Metab. Dispos. 35 (8): 1292–300. PMID 17470523. doi:10.1124/dmd.107.015354. 
  6. Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3. http://books.mcgraw-hill.com/medical/goodmanandgilman/. 


  Molimo Vas, obratite pažnju na važno upozorenje u vezi tema o zdravlju (medicini).