Karboprost
Karboprost (Hemabat, Tam) je sintetički prostaglandinski analog PGF2α (specifično, on je 15-metil-PGF2α) sa oksitoksnim svojstvima.
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (5Z,9α,11α,13E,15S)-9,11,15-trihidroksi-15- metilprosta-5,13-dien-1-oinska kiselina | |||
| Klinički podaci | |||
| AHFS/Drugs.com | Mikromedeks, detaljne potrošačke informacije | ||
| MedlinePlus | a600042 | ||
| Identifikatori | |||
| CAS broj | 58551-69-2 | ||
| ATC kod | G02AD04 | ||
| PubChem[1][2] | 5281075 | ||
| DrugBank | DB00429 | ||
| ChemSpider[3] | 4444532 | ||
| UNII | U4526F86FJ 
| ||
| ChEMBL[4] | CHEMBL1201299
| ||
| Hemijski podaci | |||
| Formula | C21H36O5 | ||
| Mol. masa | 368,508 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | ℞ Prescription only | ||
| Način primene | Intravenozno | ||
Karboprost indukuje kontrakcije i može da inicira abortus u ranoj trudnoći. On takođe redukuje porođajno krvarenje.
Indikacije
urediKoristi se za kontrolu porođajnog krvarenja uzrokovanog atonijom materice, koje se ne može kontrolisati drugim metodima.
Reference
uredi- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
Literatura
uredi- Indman P (2004). „Use of carboprost to facilitate hysteroscopic resection of submucous myomas”. J Am Assoc Gynecol Laparosc 11 (1): 68–72. DOI:10.1016/S1074-3804(05)60014-X. PMID 15104835.
- Vukelić J (2001). „Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine”. Med Pregl 54 (1–2): 11–6. PMID 11436877.
- Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). „Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation”. Urology 46 (6): 811–5. DOI:10.1016/S0090-4295(99)80349-5. PMID 7502421.
