Sabkomelin
(Preusmjereno sa stranice IQWCBYSUUOFOMF-ZRDIBKRKSA-N)
Sabkomelin (Memrik, SB-202,026) je selektivni parcijalni agonist M1 receptora. On je bio u razvoju za lečenje Alchajmerove bolesti.[5] Sabkomelin je dospeo do faze III kliničkih ispitivanja, ali su dalja ispitivanja prekinuta zbog loših rezultata.
(IUPAC) ime | |||
---|---|---|---|
(3R)-N-metoksihinuklidin-3-karboksimidoil cijanid hidrohlorid | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 159912-58-0 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 9577995 | ||
ChemSpider[3] | 7852359 | ||
UNII | P8P92V596C | ||
ChEMBL[4] | CHEMBL134641 | ||
Hemijski podaci | |||
Formula | C10H15N3O | ||
Mol. masa | 193,12 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Nije odobren |
Reference uredi
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Loudon JM, Bromidge SM, Brown F, et al. (December 1997). „SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors”. The Journal of Pharmacology and Experimental Therapeutics 283 (3): 1059–68. PMID 9399977.