Hinazolin

Hinazolin
	Hinazolin
Drugi nazivi	Benzopirimidin
Identifikacija
CAS registarski broj	253-82-7
PubChem	9210
ChemSpider	8855
ChEBI	36621
ChEMBL	CHEMBL301359
Jmol-3D slike	Slika 1
SMILES
	c1ccc2c(c1)cncn2
InChI
	InChI=1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H ; Kod: JWVCLYRUEFBMGU-UHFFFAOYSA-N InChI=1/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H; Kod: JWVCLYRUEFBMGU-UHFFFAOYAV
Svojstva
Molekulska formula	C8H6N2
Molarna masa	130,15 g/mol
pKa	3,31
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Hinazolin je jedinjenje koja se sastoji od dva kondenzovana šestočlana jednostavna aromatična prstena, benzena i pirimidina. Njegova hemijska formula je C₈H₆N₂. Hinazolin je žuta kristalan materija. Derivati hinazolina se često nazivaju hinazolinskim jedinjenjima.

U medicinskoj hemiji on se koristi u raznim oblastima, a posebno kao antimalarijski agens i kao tretman za kancer. Jedan primer jedinjenja koje sadrži hinazolinsku strukturu je doksazosin mesilat.

On je strukturni izomer sa hinoksalinom, ftalazinom i cinolinom.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.

Povezano

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.

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