Glicin hidroksimetiltransferaza
Glicin hidroksimetiltransferaza (EC 2.1.2.1, serinska aldolaza, treoninska aldolaze, serinska hidroksimetilaza, serinska hidroksimetiltransferaza, alotreoninska aldolaza, L-serinska hidroksimetiltransferaza, L-treoninska aldolaza, serinska hidroksimetiltransferaza, serinska transhidroksimetilaza) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat:glicin hidroksimetiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glicin hidroksimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Glicin hidroksimetiltransferaza 1, homotetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.2.1 | ||||||||
| CAS broj | 9029-83-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 5,10-metilintetrahidrofolat + glicin + H2O tetrahidrofolat + L-serin
Ovaj enzim je piridoksal-fosfatni protein. On takođe katalizuje reakciju glicina sa acetaldehidom čime se formira L-treonin, i sa 4-trimetilamoniobutanalom do 3-hidroksi-N6,N6,N6-trimetil-L-lizin.
Reference
uredi- ↑ Akhtar, M. and El-Obeid, H.A. (1972). „Inactivation of serine transhydroxymethylase and threonine aldolase activities”. Biochim. Biophys. Acta 258: 791-799. PMID 5017703.
- ↑ Blakley, R.L. (1960). „A spectrophotometric study of the reaction catalysed by serine transhydroxymethylase”. Biochem. J. 77: 459-465. PMID 16748851.
- ↑ Fujioka, M. (1969). „Purification and properties of serine hydroxymethylase from soluble and mitochondrial fractions of rabbit liver”. Biochim. Biophys. Acta 185: 338-349. PMID 5808700.
- ↑ Kumagai, H., Nagate, T., Yoshida, H. and Yamada, H. (1972). „Threonine aldolase from Candida humicola. II. Purification, crystallization and properties”. Biochim. Biophys. Acta 258: 779-790. PMID 5017702.
- ↑ Schirch, L.V. and Gross, T. (1968). „Serine transhydroxymethylase. Identification as the threonine and allothreonine aldolases”. J. Biol. Chem. 243: 5651-5655. PMID 5699057.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.