Galaninu-sličan peptid
Galaninu-sličan peptid (GALP) je neuropeptid koji je prisutan u telu čoveka i drugih sisara. To je polipeptid sa 60-aminokiselina koji nastaje u arkuatnom jezgru hipotalamusa i posteriornoj hipofiznoj žlijezdi.[1][2][3] On učestvuje u regulaciji apetita, i moguće je da ima druge uloge kao što su inflamacija, seksualno ponašanje, i stres.[4][5][6][7][8][9]
| Galaninu sličan peptid | |
|---|---|
| Identifikatori | |
| Simbol | GALP |
| Entrez | 85569 |
| HUGO | 24840 |
| OMIM | 611178 |
| RefSeq | NM_033106 |
| UniProt | Q9UBC7 |
| Drugi podaci | |
| Lokus | Hromozom 19 q13.42 |
Literatura
uredi- ↑ Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (February 2003). „Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis”. Neuroendocrinology 77 (2): 125–31. DOI:10.1159/000068648. PMID 12624534.
- ↑ Kageyama H, Takenoya F, Kita T, Hori T, Guan JL, Shioda S (March 2005). „Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction”. Regulatory Peptides 126 (1-2): 21–6. DOI:10.1016/j.regpep.2004.08.029. PMID 15620409.
- ↑ Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S (January 2008). „Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus”. Regulatory Peptides 145 (1-3): 165–8. DOI:10.1016/j.regpep.2007.08.019. PMID 17916390.
- ↑ Man PS, Lawrence CB (July 2008). „Galanin-like peptide: a role in the homeostatic regulation of energy balance?”. Neuropharmacology 55 (1): 1–7. DOI:10.1016/j.neuropharm.2008.04.008. PMID 18538801.
- ↑ Kuramochi M, Onaka T, Kohno D, Kato S, Yada T (April 2006). „Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat”. Endocrinology 147 (4): 1744–52. DOI:10.1210/en.2005-0907. PMID 16410310.
- ↑ Taylor A, Madison FN, Fraley GS (March 2009). „Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats”. Journal of Chemical Neuroanatomy 37 (2): 105–11. DOI:10.1016/j.jchemneu.2008.12.003. PMID 19124073.
- ↑ Man PS, Lawrence CB (November 2008). „Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide”. Endocrinology 149 (11): 5791–802. DOI:10.1210/en.2008-0252. PMID 18617619.
- ↑ Lawrence CB (July 2009). „Galanin-like peptide modulates energy balance by affecting inflammatory mediators?”. Physiology & Behavior 97 (5): 515–9. DOI:10.1016/j.physbeh.2009.02.041. PMID 19298833.
- ↑ Suzuki H, Onaka T, Dayanithi G, Ueta Y (June 2009). „Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland”. Pathophysiology 17 (2): 135–140. DOI:10.1016/j.pathophys.2009.03.007. PMID 19501488.