Farmakogenetika

Farmakogenetika se bavi genetičkim razlikama u metaboličkim putemiva koji utiču na individualne response na lekove, u pogledu terapeutskog dejstva i nuspojava.^[1]

U onkologiji se farmakogenetika tradicionalno odnosi na gonocitne mutacije (e.g., jednonukleotidne polimorfizame gena koji kodiraju enzime jetre odgovorne za uklanjanje lekova i farmakokinetiku), dok se farmakogenomika odnosi na somatske mutacije u tumorskoj DNK koji uzrokuju promene u responsu na lek (e.g., KRAS mutacije kod pacijenata tretiranih sa anti-Her1 biološkim agensima).^[2]

Reference

↑ Klotz, U. (2007). „The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications.”. Clin Pharmacokinet 46 (4): 271–9. PMID 17375979.
↑ Roses AD (June 2000). „Pharmacogenetics and the practice of medicine”. Nature 405 (6788): 857–65. DOI:10.1038/35015728. PMID 10866212.

Literatura

Abbott A (October 2003). „With your genes? Take one of these, three times a day”. Nature 425 (6960): 760–2. DOI:10.1038/425760a. PMID 14574377.
Evans WE, McLeod HL (February 2003). „Pharmacogenomics – drug disposition, drug targets, and side effects”. N. Engl. J. Med. 348 (6): 538–49. DOI:10.1056/NEJMra020526. PMID 12571262.
Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (November 2001). „Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review”. JAMA 286 (18): 2270–9. DOI:10.1001/jama.286.18.2270. PMID 11710893.
Weinshilboum R; Collins, Francis S.; Weinshilboum, Richard (February 2003). „Inheritance and drug response”. N. Engl. J. Med. 348 (6): 529–37. DOI:10.1056/NEJMra020021. PMID 12571261.

Povezano

Vanjske veze

Pharmacogenomics: Medicine and the new genetics from the Human Genome Project
Pharmacogenomics in Drug Discovery and Development, a book on pharmacogenomics, diseases, personalized medicine, and therapeutics
The Pharmacogenomics Journal
PharmGKB The Pharmacogenetics and Pharmacogenomics Knowledge Base, a free online tool for Pharmacogenetics research

[Klotz-2007-1] Klotz, U. (2007). „The role of pharmacogenetics in the metabolism of antiepileptic drugs: pharmacokinetic and therapeutic implications.”. Clin Pharmacokinet 46 (4): 271–9. PMID 17375979.

[pmid10866212-2] Roses AD (June 2000). „Pharmacogenetics and the practice of medicine”. Nature 405 (6788): 857–65. DOI:10.1038/35015728. PMID 10866212.

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