Interleukin 33

Interleukin 33
Identifikatori
Simbol	IL33
Alt. simboli	DV27, C9ORF26, IL1F11, NFHEV
Entrez	90865
Hugo	16028
OMIM	608678
RefSek	NM_033439
UniProt	O95760
Drugi podaci
Lokus	Hrom. 9 p24.1

Interleukin 33 (IL-33) je citokin iz IL-1 superfamilije. IL-33 podstiče T pomoćne ćelije, mastocite, eosinofile i bazofile da proizvode tip 2 citokine.^[1] Ovaj citokin se ranije zvao NF-HEV 'nuklearni faktor (NF) u visokim endotelijalnim venama' (engl. nuclear factor in high endothelial venules)' pošto je originalno identifikovan u tim specijalizovanim ćelijama.^[2] IL-33 posreduje biološke efekte putem interakcija sa receptorima ST2 (ili IL1RL1) i IL-1 receptor ancestorskim proteinom (IL1RAP), aktivirajući intracelularne molekule u NF-κB i MAP kinaza signalnom putu koji uslovljavaju proizvodnju tipa 2 citokina (npr. IL-5 i IL-13) iz polarizovanih Th₂ ćelija. Indukcija tipa 2 citokina putem IL-33 in-vivo se smatra da uzrokuje ozbiljne patološke promene primećene u mukoznim organima nakon IL-33 administracije.^[3]^[4]^[5]

Reference

↑ Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.
↑ Baekkevold ES, Roussigné M, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F, Brandtzaeg P, Erard M, Haraldsen G, Girard JP (July 2003). „Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules”. Am. J. Pathol. 163 (1): 69–79. PMC 1868188. PMID 12819012.
↑ Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA (November 2005). „IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines”. Immunity 23 (5): 479–90. DOI:10.1016/j.immuni.2005.09.015. PMID 16286016.
↑ Chackerian AA, Oldham ER, Murphy EE, Schmitz J, Pflanz S, Kastelein RA (August 2007). „IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex”. J. Immunol. 179 (4): 2551–5. PMID 17675517.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

Spoljašnje veze

MeSH Interleukin-33

Wikimedia Commons ima multimedijalne datoteke vezane za: Interleukin 33

[KubyImmunology6th-1] Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby (2006). Kuby Immunology (6 izd.). New York: W H Freeman and company. ISBN 1-4292-0211-4.

[pmid12819012-2] Baekkevold ES, Roussigné M, Yamanaka T, Johansen FE, Jahnsen FL, Amalric F, Brandtzaeg P, Erard M, Haraldsen G, Girard JP (July 2003). „Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules”. Am. J. Pathol. 163 (1): 69–79. PMC 1868188. PMID 12819012.

[pmid16286016-3] Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA (November 2005). „IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines”. Immunity 23 (5): 479–90. DOI:10.1016/j.immuni.2005.09.015. PMID 16286016.

[pmid17675517-4] Chackerian AA, Oldham ER, Murphy EE, Schmitz J, Pflanz S, Kastelein RA (August 2007). „IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex”. J. Immunol. 179 (4): 2551–5. PMID 17675517.

[5] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

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