CCL11

Hemokin (C-C motiv) ligand 11
	; PDB prikaz baziran na 1eot.
Dostupne strukture
	1eot, 2eot
Identifikatori
Simboli	CCL11; MGC22554; SCYA11
Vanjski ID	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11 Gene
Ontologija gena
Molekularna funkcija	• hemokinska aktivnost;
Celularna komponenta	• ekstracelularni region; • ekstracelularni prostor;
Biološki proces	• proteinska aminokiselinska fosforilacija; • ćelijska homeostaza kalcijum jona; • hemotaksa; • inflamatorni odgovor; • imunski odgovor; • ćelijski odbrambeni respons; • ćelijska adhezija; • transdukcija signala; • interćelijska signalizacija; • respons na radijaciju; • respons na viruse;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

CCL11, hemokin (C-C motiv) ligand 11, je mali citokin iz CC hemokin familije. On je takođe poznat kao eotaksin-1. CCL11 selektivno regrutuje eozinofile putem indukovanja njihove hemotakse, i zato je impliciran u alergijske response.^[1]^[2]^[3]

Efekti CCL11 su posredovani njegovim vezivanjem za G-protein spregnuti hemokin receptor. Hemokin receptori CCL11 liganda su CCR2^[4], CCR3^[5] i CCR5.^[4] Međutim, bilo je ustanovljeno da eotaksin-1 (CCL11) ima visok stepen selektivnosti za CCR3 receptor, tako da je neaktivan na neutrofilima i monocitima, koji ne izražavaju CCR3.^[6] Gen ljudskog CCL11 (SCYA11) je kodiran sa tri eksona i lociran je na hromozomu 17.^[7]^[5]

Reference uredi

↑ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils”. J. Clin. Invest. 97 (3): 604–12. DOI:10.1172/JCI118456. PMC 507095. PMID 8609214.
↑ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia”. Nat. Med. 2 (4): 449–56. DOI:10.1038/nm0496-449. PMID 8597956.
↑ Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.
↑ ^4,0 ^4,1 Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). „Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5”. Blood 97 (7): 1920–4. DOI:10.1182/blood.V97.7.1920. PMID 11264152.
↑ ^5,0 ^5,1 Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3”. J. Biol. Chem. 271 (13): 7725–30. DOI:10.1074/jbc.271.13.7725. PMID 8631813.
↑ Baggiolini M, Dewald B, Moser B (1997). „Human chemokines: an update”. Annu. Rev. Immunol. 15: 675–705. DOI:10.1146/annurev.immunol.15.1.675. PMID 9143704.
↑ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene”. Biochem. Biophys. Res. Commun. 237 (3): 537–42. DOI:10.1006/bbrc.1997.7169. PMID 9299399.

Literatura uredi

Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, et al. (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.”. Nat. Med. 2 (4): 449–56. DOI:10.1038/nm0496-449. PMID 8597956.
Ponath PD, Qin S, Ringler DJ, et al. (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.”. J. Clin. Invest. 97 (3): 604–12. DOI:10.1172/JCI118456. PMC 507095. PMID 8609214.
Kitaura M, Nakajima T, Imai T, et al. (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.”. J. Biol. Chem. 271 (13): 7725–30. DOI:10.1074/jbc.271.13.7725. PMID 8631813.
Daugherty BL, Siciliano SJ, DeMartino JA, et al. (1996). „Cloning, expression, and characterization of the human eosinophil eotaxin receptor.”. J. Exp. Med. 183 (5): 2349–54. DOI:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
Choe H, Farzan M, Sun Y, et al. (1996). „The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.”. Cell 85 (7): 1135–48. DOI:10.1016/S0092-8674(00)81313-6. PMID 8674119.
Ponath PD, Qin S, Post TW, et al. (1996). „Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.”. J. Exp. Med. 183 (6): 2437–48. DOI:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
Bartels J, Schlüter C, Richter E, et al. (1996). „Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.”. Biochem. Biophys. Res. Commun. 225 (3): 1045–51. DOI:10.1006/bbrc.1996.1292. PMID 8780731.
Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, et al. (1997). „Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.”. Genomics 41 (3): 471–6. DOI:10.1006/geno.1997.4656. PMID 9169149.
Hein H, Schlüter C, Kulke R, et al. (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.”. Biochem. Biophys. Res. Commun. 237 (3): 537–42. DOI:10.1006/bbrc.1997.7169. PMID 9299399.
Nibbs RJ, Wylie SM, Yang J, et al. (1998). „Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.”. J. Biol. Chem. 272 (51): 32078–83. DOI:10.1074/jbc.272.51.32078. PMID 9405404.
Rubbert A, Combadiere C, Ostrowski M, et al. (1998). „Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.”. J. Immunol. 160 (8): 3933–41. PMID 9558100.
Noso N, Bartels J, Mallet AI, et al. (1998). „Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.”. Eur. J. Biochem. 253 (1): 114–22. DOI:10.1046/j.1432-1327.1998.2530114.x. PMID 9578468.
Crump MP, Rajarathnam K, Kim KS, et al. (1998). „Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.”. J. Biol. Chem. 273 (35): 22471–9. DOI:10.1074/jbc.273.35.22471. PMID 9712872.
Sabroe I, Hartnell A, Jopling LA, et al. (1999). „Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.”. J. Immunol. 162 (5): 2946–55. PMID 10072545.
Jinquan T, Quan S, Feili G, et al. (1999). „Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.”. J. Immunol. 162 (7): 4285–92. PMID 10201960.
Klein RS, Williams KC, Alvarez-Hernandez X, et al. (1999). „Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.”. J. Immunol. 163 (3): 1636–46. PMID 10415069.
Blanpain C, Migeotte I, Lee B, et al. (1999). „CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.”. Blood 94 (6): 1899–905. PMID 10477718.
Zhang J, Lathbury LJ, Salamonsen LA (2000). „Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.”. Biol. Reprod. 62 (2): 404–11. DOI:10.1095/biolreprod62.2.404. PMID 10642580.
Kampen GT, Stafford S, Adachi T, et al. (2000). „Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.”. Blood 95 (6): 1911–7. PMID 10706854.
Huber MA, Kraut N, Addicks T, Peter RU (2000). „Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation.”. Biochem. Biophys. Res. Commun. 269 (2): 546–52. DOI:10.1006/bbrc.2000.2287. PMID 10708591.

Spoljašnje veze uredi

CCL11 GeneCard

[pmid8609214-1] Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). „Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils”. J. Clin. Invest. 97 (3): 604–12. DOI:10.1172/JCI118456. PMC 507095. PMID 8609214.

[pmid8597956-2] Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). „Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia”. Nat. Med. 2 (4): 449–56. DOI:10.1038/nm0496-449. PMID 8597956.

[3] Mire-Sluis, Anthony R.; Thorpe, Robin, ur. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5.

[pmid11264152-4] 4,0 ^4,1 Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). „Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5”. Blood 97 (7): 1920–4. DOI:10.1182/blood.V97.7.1920. PMID 11264152.

[pmid8631813-5] 5,0 ^5,1 Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). „Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3”. J. Biol. Chem. 271 (13): 7725–30. DOI:10.1074/jbc.271.13.7725. PMID 8631813.

[pmid9143704-6] Baggiolini M, Dewald B, Moser B (1997). „Human chemokines: an update”. Annu. Rev. Immunol. 15: 675–705. DOI:10.1146/annurev.immunol.15.1.675. PMID 9143704.

[pmid9299399-7] Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). „Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene”. Biochem. Biophys. Res. Commun. 237 (3): 537–42. DOI:10.1006/bbrc.1997.7169. PMID 9299399.

[1]

[2]

[3]

[4]

[5]

[6]

[7]