Bay R 1531

Bay R 1531
(IUPAC) ime
	1,3,4,5-tetrahidro-6-metoksi-N,N-dipropil-benz[cd]indol-4-amin
Klinički podaci
Identifikatori
CAS broj	98770-54-8
ATC kod	nije dodeljen
PubChem	127153
ChemSpider	112872
Hemijski podaci
Formula	C18H28N2O
Mol. masa	288,427 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H26N2O/c1-4-8-20(9-5-2)14-10-13-12-19-16-6-7-17(21-3)15(11-14)18(13)16/h6-7,12,14,19H,4-5,8-11H2,1-3H3 ; Key: BMZWFSGTPJUKJR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Bay R 1531 je triciklični triptaminski derivat koji deluje kao selektivni agonist serotoninskog receptora 5-HT_1A. On je neuspešno istraživan za tretman moždanog udara. Bay R 1531 se i dalje koristi u naučnim istraživanjima.^[4]^[5]^[6]^[7]

Reference uredi

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Bielenberg GW, Burkhardt M. 5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment. Stroke. 1990 Dec;21(12 Suppl):IV161-3. PMID 2148035
↑ Critchley MA, Njung'e K, Handley SL. Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions. Psychopharmacology (Berlin). 1992;106(4):484-90. PMID 1533721
↑ Canto de Souza A, Nunes de Souza RL, Péla IR, Graeff FG. High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors. Pharmacology, Biochemistry and Behavior. 1997 Mar;56(3):481-6. PMID 9077586
↑ Canto-de-Souza A, Nunes de Souza RL, Pelá IR, Graeff FG. Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice. European Journal of Pharmacology. 1998 Mar 26;345(3):253-6. PMID 9592023

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Bielenberg GW, Burkhardt M. 5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment. Stroke. 1990 Dec;21(12 Suppl):IV161-3. PMID 2148035

[5] Critchley MA, Njung'e K, Handley SL. Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions. Psychopharmacology (Berlin). 1992;106(4):484-90. PMID 1533721

[6] Canto de Souza A, Nunes de Souza RL, Péla IR, Graeff FG. High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors. Pharmacology, Biochemistry and Behavior. 1997 Mar;56(3):481-6. PMID 9077586

[7] Canto-de-Souza A, Nunes de Souza RL, Pelá IR, Graeff FG. Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice. European Journal of Pharmacology. 1998 Mar 26;345(3):253-6. PMID 9592023

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