Almokalant

Almokalant
(IUPAC) ime
	4-(3-{Etil[3-(propan-1-sulfinil)propil]amino2-hidroksipropokss)benzonitril
Klinički podaci
Identifikatori
CAS broj	123955-10-2
ATC kod	nije dodeljen
PubChem	3033962
ChemSpider	2298526
UNII	I9NG89L275
ChEMBL	CHEMBL362103
Hemijski podaci
Formula	C18H28N2O3S
Mol. masa	352,5 g/mol
InChI
	InChI=1S/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3 ; Key: ZMHOBBKJBYLXFR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Almokalant je lek koji se koristi za tretiranje aritmije.^[5] On je blokator kalijumovog kanala. Putem experimenata na pacovima je utvrđeno da ima teratogene efekte.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Wiesfeld A C; Crijns H J; Bergstrand R H; Almgren O; Hillege H L; Lie K I (1993). „Torsades de pointes with Almokalant, a new class III antiarrhythmic drug”. American heart journal 126 (4): 1008–1011.
↑ Signs of Almokalant - Teratogenic Agent, wrongdiagnosis.com

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Wiesfeld A C; Crijns H J; Bergstrand R H; Almgren O; Hillege H L; Lie K I (1993). „Torsades de pointes with Almokalant, a new class III antiarrhythmic drug”. American heart journal 126 (4): 1008–1011.

[6] Signs of Almokalant - Teratogenic Agent, wrongdiagnosis.com

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