Adatanserin

Adatanserin
(IUPAC) ime
	N-[2-(4-pirimidin-2-ilpiperazin-1-il)etil]adamantan-1-karboksamid
Klinički podaci
Identifikatori
CAS broj	127266-56-2
ATC kod	nije dodeljen
PubChem	130918
ChemSpider	115774
UNII	W5U6WQM26H
Hemijski podaci
Formula	C21H31N5O
Mol. masa	369,50 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27) ; Key: HPFLVTSWRFCPCV-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Adatanserin (WY-50,324, SEB-324) je mešoviti 5-HT_1A receptor parcijalni agonist i antagonist 5-HT_2A i 5-HT_2C receptora.^[4]^[5]^[6] On je razvijan kao kao antidepresiv ali je razboj zaustavljen.^[6]^[7]

Adantaserin poseduje neuroprotektivna svojstva protiv ishemijom indukovane glutamatergičke ekscitotoksičnosti. Taj efekat je posredovan blokadom 5-HT_2A receptora.^[8]

Povezano

Flibanserin

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Singh A, Lucki I (April 1993). „Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors”. Neuropharmacology 32 (4): 331–40. DOI:10.1016/0028-3908(93)90153-T. PMID 8497336.
↑ Kleven MS, Koek W (February 1996). „Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon”. The Journal of Pharmacology and Experimental Therapeutics 276 (2): 388–97. PMID 8632301.
↑ ^6,0 ^6,1 Abou-Gharbia MA, Childers WE, Fletcher H, et al. (December 1999). „Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents”. Journal of Medicinal Chemistry 42 (25): 5077–94. DOI:10.1021/jm9806704. PMID 10602693.
↑ Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4.
↑ Dawson LA, Galandak J, Djali S (March 2002). „Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin”. Neurochemistry International 40 (3): 203–9. DOI:10.1016/S0197-0186(01)00082-1. PMID 11741003.

Literatura

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid8497336-4] Singh A, Lucki I (April 1993). „Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors”. Neuropharmacology 32 (4): 331–40. DOI:10.1016/0028-3908(93)90153-T. PMID 8497336.

[pmid8632301-5] Kleven MS, Koek W (February 1996). „Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon”. The Journal of Pharmacology and Experimental Therapeutics 276 (2): 388–97. PMID 8632301.

[pmid10602693-6] 6,0 ^6,1 Abou-Gharbia MA, Childers WE, Fletcher H, et al. (December 1999). „Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents”. Journal of Medicinal Chemistry 42 (25): 5077–94. DOI:10.1021/jm9806704. PMID 10602693.

[isbn0-521-64615-4-7] Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4.

[pmid11741003-8] Dawson LA, Galandak J, Djali S (March 2002). „Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin”. Neurochemistry International 40 (3): 203–9. DOI:10.1016/S0197-0186(01)00082-1. PMID 11741003.

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